Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study
Abstract Background Adenomyosis is a common gynecological disease in women of reproductive age and causes various symptoms such as dysmenorrhea and heavy menstrual bleeding. However, the influence of pregnancy on the progression of adenomyosis remains unclear. The insight into whether the size of ad...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-05956-0 |
| _version_ | 1827632769791950848 |
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| author | Daiki Hiratsuka Erika Omura Chihiro Ishizawa Rei Iida Yamato Fukui Takehiro Hiraoka Shun Akaeda Mitsunori Matsuo Miyuki Harada Osamu Wada-Hiraike Yutaka Osuga Yasushi Hirota |
| author_facet | Daiki Hiratsuka Erika Omura Chihiro Ishizawa Rei Iida Yamato Fukui Takehiro Hiraoka Shun Akaeda Mitsunori Matsuo Miyuki Harada Osamu Wada-Hiraike Yutaka Osuga Yasushi Hirota |
| author_sort | Daiki Hiratsuka |
| collection | DOAJ |
| description | Abstract Background Adenomyosis is a common gynecological disease in women of reproductive age and causes various symptoms such as dysmenorrhea and heavy menstrual bleeding. However, the influence of pregnancy on the progression of adenomyosis remains unclear. The insight into whether the size of adenomyosis is increased, decreased, or unchanged during pregnancy is also undetermined. The current study aimed to evaluate the influence of pregnancy in patients with symptomatic adenomyosis. Methods This study retrospectively enrolled patients diagnosed with adenomyosis by magnetic resonance imaging between 2015 and 2022 at The University of Tokyo Hospital. Uterine size changes were evaluated by two imaging examinations. In the pregnancy group, the patients did not receive any hormonal and surgical treatments, except cesarean section, but experienced pregnancy and delivery between the first and second imaging examinations. In the control group (nonpregnancy group), the patients experienced neither hormonal and surgical treatments nor pregnancy from at least 1 year before the first imaging to the second imaging. The enlargement rate of the uterine size per year (percentage) was calculated by the uterine volume changes (cm3) divided by the interval (years) between two imaging examinations. The enlargement rate of the uterine size per year was compared between the pregnancy group and the control group. Results Thirteen and 11 patients with symptomatic adenomyosis were included in the pregnancy group and in the control group, respectively. The pregnancy group had a lower enlargement rate per year than the control group (mean ± SE: −7.4% ± 3.6% vs. 48.0% ± 18.5%, P < 0.001), indicating that the size of the uterus with adenomyosis did not change in the pregnancy group. Conclusions Pregnancy is associated with reduced progression of symptomatic adenomyosis. |
| first_indexed | 2024-03-09T14:50:14Z |
| format | Article |
| id | doaj.art-47e8b6d7a8c14c978564ccec2f43071b |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-09T14:50:14Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-47e8b6d7a8c14c978564ccec2f43071b2023-11-26T14:30:56ZengBMCBMC Pregnancy and Childbirth1471-23932023-09-0123111010.1186/s12884-023-05956-0Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot studyDaiki Hiratsuka0Erika Omura1Chihiro Ishizawa2Rei Iida3Yamato Fukui4Takehiro Hiraoka5Shun Akaeda6Mitsunori Matsuo7Miyuki Harada8Osamu Wada-Hiraike9Yutaka Osuga10Yasushi Hirota11Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of TokyoAbstract Background Adenomyosis is a common gynecological disease in women of reproductive age and causes various symptoms such as dysmenorrhea and heavy menstrual bleeding. However, the influence of pregnancy on the progression of adenomyosis remains unclear. The insight into whether the size of adenomyosis is increased, decreased, or unchanged during pregnancy is also undetermined. The current study aimed to evaluate the influence of pregnancy in patients with symptomatic adenomyosis. Methods This study retrospectively enrolled patients diagnosed with adenomyosis by magnetic resonance imaging between 2015 and 2022 at The University of Tokyo Hospital. Uterine size changes were evaluated by two imaging examinations. In the pregnancy group, the patients did not receive any hormonal and surgical treatments, except cesarean section, but experienced pregnancy and delivery between the first and second imaging examinations. In the control group (nonpregnancy group), the patients experienced neither hormonal and surgical treatments nor pregnancy from at least 1 year before the first imaging to the second imaging. The enlargement rate of the uterine size per year (percentage) was calculated by the uterine volume changes (cm3) divided by the interval (years) between two imaging examinations. The enlargement rate of the uterine size per year was compared between the pregnancy group and the control group. Results Thirteen and 11 patients with symptomatic adenomyosis were included in the pregnancy group and in the control group, respectively. The pregnancy group had a lower enlargement rate per year than the control group (mean ± SE: −7.4% ± 3.6% vs. 48.0% ± 18.5%, P < 0.001), indicating that the size of the uterus with adenomyosis did not change in the pregnancy group. Conclusions Pregnancy is associated with reduced progression of symptomatic adenomyosis.https://doi.org/10.1186/s12884-023-05956-0AdenomyosisChildbirth experienceMagnetic resonance imagingPregnancyUterine size |
| spellingShingle | Daiki Hiratsuka Erika Omura Chihiro Ishizawa Rei Iida Yamato Fukui Takehiro Hiraoka Shun Akaeda Mitsunori Matsuo Miyuki Harada Osamu Wada-Hiraike Yutaka Osuga Yasushi Hirota Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study BMC Pregnancy and Childbirth Adenomyosis Childbirth experience Magnetic resonance imaging Pregnancy Uterine size |
| title | Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study |
| title_full | Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study |
| title_fullStr | Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study |
| title_full_unstemmed | Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study |
| title_short | Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study |
| title_sort | pregnancy is associated with reduced progression of symptomatic adenomyosis a retrospective pilot study |
| topic | Adenomyosis Childbirth experience Magnetic resonance imaging Pregnancy Uterine size |
| url | https://doi.org/10.1186/s12884-023-05956-0 |
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