Cutoff value of IC50 for drug sensitivity in patient-derived tumor organoids in colorectal cancer

Cutoff value of IC50 for drug sensitivity in patient-derived tumor organoids in colorectal cancer

Summary: Patient-derived tumor organoids (PDTOs) have the potential to be used to predict the patient response to chemotherapy. However, the cutoff value of the half-maximal inhibition concentration (IC50) for PDTO drug sensitivity has not been validated with clinical cohort data. We established PDT...

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Bibliographic Details
Main Authors: Yuting Tang, Ting Wang, Yaowen Hu, Hongli Ji, Botao Yan, Xiarong Hu, Yunli Zeng, Yifan Hao, Weisong Xue, Zexin Chen, Jianqiang Lan, Yanan Wang, Haijun Deng, Chuxia Deng, Xiufeng Wu, Jun Yan
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Cancer
Drugs
Molecular modelling
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223011938

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