Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyond
Venous invasion (VI) is a well-established independent prognostic indicator in colorectal cancer (CRC). Its accurate detection is particularly important in stage II CRC as it may influence the decision to administer adjuvant therapy. The Royal College of Pathologists (RCPath) of the United Kingdom...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00354/full |
| _version_ | 1819267970517434368 |
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| author | Heather eDawson Heather eDawson Richard eKirsch David eDriman David eMessenger Naziheh eAssarzadegan Robert eRiddell |
| author_facet | Heather eDawson Heather eDawson Richard eKirsch David eDriman David eMessenger Naziheh eAssarzadegan Robert eRiddell |
| author_sort | Heather eDawson |
| collection | DOAJ |
| description | Venous invasion (VI) is a well-established independent prognostic indicator in colorectal cancer (CRC). Its accurate detection is particularly important in stage II CRC as it may influence the decision to administer adjuvant therapy. The Royal College of Pathologists (RCPath) of the United Kingdom state that VI should be detected in at least 30% of CRC resection specimens. However, our experience in Ontario, Canada suggests that this (conservative) benchmark is rarely met. This article highlights the Ontario experience with respect to VI reporting and the key role that careful morphologic assessment, elastin staining and knowledge transfer has played in improving VI detection provincially and beyond. |
| first_indexed | 2024-12-23T21:25:38Z |
| format | Article |
| id | doaj.art-47ea24659ca74d63a63692ae80589cd6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T21:25:38Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-47ea24659ca74d63a63692ae80589cd62022-12-21T17:30:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-01-01410.3389/fonc.2014.00354121021Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyondHeather eDawson0Heather eDawson1Richard eKirsch2David eDriman3David eMessenger4Naziheh eAssarzadegan5Robert eRiddell6Clinical Pathology Division, Institute of Pathology, University of BernMount Sinai HospitalMount Sinai HospitalLondon Health Sciences Centre, Western UniversityTaunton and Somerset NHS FoundationMount Sinai HospitalMount Sinai HospitalVenous invasion (VI) is a well-established independent prognostic indicator in colorectal cancer (CRC). Its accurate detection is particularly important in stage II CRC as it may influence the decision to administer adjuvant therapy. The Royal College of Pathologists (RCPath) of the United Kingdom state that VI should be detected in at least 30% of CRC resection specimens. However, our experience in Ontario, Canada suggests that this (conservative) benchmark is rarely met. This article highlights the Ontario experience with respect to VI reporting and the key role that careful morphologic assessment, elastin staining and knowledge transfer has played in improving VI detection provincially and beyond.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00354/fullcolorectal cancer (CRC)prognostic markervenous invasionelastin stainstage II colorectal cancer |
| spellingShingle | Heather eDawson Heather eDawson Richard eKirsch David eDriman David eMessenger Naziheh eAssarzadegan Robert eRiddell Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyond Frontiers in Oncology colorectal cancer (CRC) prognostic marker venous invasion elastin stain stage II colorectal cancer |
| title | Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyond |
| title_full | Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyond |
| title_fullStr | Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyond |
| title_full_unstemmed | Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyond |
| title_short | Optimizing the detection of venous invasion in colorectal cancer: The Ontario, Canada, experience and beyond |
| title_sort | optimizing the detection of venous invasion in colorectal cancer the ontario canada experience and beyond |
| topic | colorectal cancer (CRC) prognostic marker venous invasion elastin stain stage II colorectal cancer |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00354/full |
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