Overcoming chemotherapy resistance using pH-sensitive hollow MnO2 nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma

Overcoming chemotherapy resistance using pH-sensitive hollow MnO2 nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma

Abstract Background Smart nanoscale drug delivery systems that target acidic tumor microenvironments (TME) could offer controlled release of drugs and modulate the hypoxic TME to enhance cancer therapy. The majority of previously reported MnO2 nanostructures are nanoparticles, nanosheets, or nanocom...

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Bibliographic Details
Main Authors: Zhi-hang Zhou, Si-yuan Liang, Tong-chao Zhao, Xu-zhuo Chen, Xian-kun Cao, Ming Qi, Ying-ying Huang, Wu-tong Ju, Meng Yang, Dong-wang Zhu, Yi-chuan Pang, Lai-ping Zhong
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Nanobiotechnology
Subjects:
MnO2
Tumor microenvironment
Oral squamous cell carcinoma
Hypoxia
Angiogenesis
Chemotherapy
Online Access:https://doi.org/10.1186/s12951-021-00901-9

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