Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel disease
Despite the recent advances in treatment, some patients with inflammatory bowel disease (IBD) experience insufficient disease management and adverse side effects, necessitating the development of novel therapeutic strategies. We investigated the therapeutic efficacy of exosome-like nanoparticles (NP...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000094 |
| _version_ | 1797356116442611712 |
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| author | Woo Sik Kim Seo Jun Lee Ki-Won Shin Hyeon Jin Lee Ji Young Park In Chul Lee Hyung-Jun Kwon Hyung Jae Jeong Bong-Sik Yun Young Bae Ryu |
| author_facet | Woo Sik Kim Seo Jun Lee Ki-Won Shin Hyeon Jin Lee Ji Young Park In Chul Lee Hyung-Jun Kwon Hyung Jae Jeong Bong-Sik Yun Young Bae Ryu |
| author_sort | Woo Sik Kim |
| collection | DOAJ |
| description | Despite the recent advances in treatment, some patients with inflammatory bowel disease (IBD) experience insufficient disease management and adverse side effects, necessitating the development of novel therapeutic strategies. We investigated the therapeutic efficacy of exosome-like nanoparticles (NPs) derived from Boehmeria japonica (BJ-NPs) in treating IBD. These BJ-NPs increased immunosuppressive cytokine IL-10 production (p < 0.001) in mature dendritic cells (DCs) and reduced the levels of pro-inflammatory cytokines and surface molecules. Moreover, BJ-NP-treated DCs exhibited decreased immunostimulatory capacity for inducing activation of Th1 and Th17 subsets while promoting regulatory T cell activity. In a colitis animal model, BJ-NP administration mitigated weight loss (p < 0.001 at 4–10 days), improved disease activity index scores (p < 0.001 at 6–10 days), reduced colon length (p < 0.001), and ameliorated histological features. These findings suggest that BJ-NPs can be used as nutraceutical or therapeutic agent for various inflammatory diseases, including IBD. |
| first_indexed | 2024-03-08T14:20:58Z |
| format | Article |
| id | doaj.art-47ec38b5f22a403aa456905a849763b6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:20:58Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-47ec38b5f22a403aa456905a849763b62024-01-14T05:37:32ZengElsevierJournal of Functional Foods1756-46462024-01-01112106007Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel diseaseWoo Sik Kim0Seo Jun Lee1Ki-Won Shin2Hyeon Jin Lee3Ji Young Park4In Chul Lee5Hyung-Jun Kwon6Hyung Jae Jeong7Bong-Sik Yun8Young Bae Ryu9Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of KoreaFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of Korea; Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, Jeonbuk 54596, Republic of KoreaFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of Korea; Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of Korea; Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of KoreaFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of KoreaFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of KoreaFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of KoreaDivision of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, Jeonbuk 54596, Republic of Korea; Corresponding authors at: Division of Biotechnology and Advanced Institute of Environment and Bioscience, Jeonbuk National University, Iksan-si, Jeollabuk-do 54596, Republic of Korea.Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Republic of Korea; Corresponding authors at: Division of Biotechnology and Advanced Institute of Environment and Bioscience, Jeonbuk National University, Iksan-si, Jeollabuk-do 54596, Republic of Korea.Despite the recent advances in treatment, some patients with inflammatory bowel disease (IBD) experience insufficient disease management and adverse side effects, necessitating the development of novel therapeutic strategies. We investigated the therapeutic efficacy of exosome-like nanoparticles (NPs) derived from Boehmeria japonica (BJ-NPs) in treating IBD. These BJ-NPs increased immunosuppressive cytokine IL-10 production (p < 0.001) in mature dendritic cells (DCs) and reduced the levels of pro-inflammatory cytokines and surface molecules. Moreover, BJ-NP-treated DCs exhibited decreased immunostimulatory capacity for inducing activation of Th1 and Th17 subsets while promoting regulatory T cell activity. In a colitis animal model, BJ-NP administration mitigated weight loss (p < 0.001 at 4–10 days), improved disease activity index scores (p < 0.001 at 6–10 days), reduced colon length (p < 0.001), and ameliorated histological features. These findings suggest that BJ-NPs can be used as nutraceutical or therapeutic agent for various inflammatory diseases, including IBD.http://www.sciencedirect.com/science/article/pii/S1756464624000094Boehmeria japonicaPlant-derived exosome-like nanoparticlesDendritic cellsImmune toleranceInflammatory bowel disease |
| spellingShingle | Woo Sik Kim Seo Jun Lee Ki-Won Shin Hyeon Jin Lee Ji Young Park In Chul Lee Hyung-Jun Kwon Hyung Jae Jeong Bong-Sik Yun Young Bae Ryu Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel disease Journal of Functional Foods Boehmeria japonica Plant-derived exosome-like nanoparticles Dendritic cells Immune tolerance Inflammatory bowel disease |
| title | Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel disease |
| title_full | Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel disease |
| title_fullStr | Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel disease |
| title_full_unstemmed | Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel disease |
| title_short | Nutraceutical potential of exosome-like nanoparticles derived from Boehmeria japonica in inflammatory bowel disease |
| title_sort | nutraceutical potential of exosome like nanoparticles derived from boehmeria japonica in inflammatory bowel disease |
| topic | Boehmeria japonica Plant-derived exosome-like nanoparticles Dendritic cells Immune tolerance Inflammatory bowel disease |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000094 |
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