Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment
A mixed Chinese herbal formula, Xiao-Qing-Long-Decoction (XQLD), may contribute to sustained remission in allergic rhinitis (AR), but it is unknown which factors determine such long-term effect. Here, we aimed to identify bacterial signatures associated with sustained remission. To this end, samples...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.774966/full |
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| author | Libing Zhu Libing Zhu Yuning Wu Chenglong Lin Lin Tang Bin Yu Wenrong Wan Jingxiu Xuan Yanling Du Zhangran Chen Wei Liang |
| author_facet | Libing Zhu Libing Zhu Yuning Wu Chenglong Lin Lin Tang Bin Yu Wenrong Wan Jingxiu Xuan Yanling Du Zhangran Chen Wei Liang |
| author_sort | Libing Zhu |
| collection | DOAJ |
| description | A mixed Chinese herbal formula, Xiao-Qing-Long-Decoction (XQLD), may contribute to sustained remission in allergic rhinitis (AR), but it is unknown which factors determine such long-term effect. Here, we aimed to identify bacterial signatures associated with sustained remission. To this end, samples from AR patients at four different times were analyzed to compare the dynamic bacterial community and structure shifts. Diversity indices Chao1 showed significant difference across different time (p<0.05), and the Kruskal-Wallis test identified that Dialister (OTU_31), Roseburia (OTU_36), Bacteroides (OTU_22), Bacteroides (OTU_2040), and Prevotella_9 (OTU_5) were the significant differential bacterial taxa (p<0.05). These distinctive genera were significantly associated with the change of AR clinical indices and the predicted functional pathways such as PPAR signaling pathway, peroxisome, and citrate cycle (TCA cycle) (p<0.05), indicating that they may be important bacterial signatures involving in the sustained remission in AR (p<0.05). Besides, lower Firmicutes/Bacteroidetes (F/B) ratio at 6 months follow-up may also contribute to the long-term remission of AR. No seriously adverse events and safety concerns were observed in this study. In conclusion, XQLD is a meaningful, long-term efficient and safe medication for AR treatment. The underlying mechanisms of sustained remission in AR after XQLD treatment may be associated with the dynamic alteration of featured gut bacteria taxa. |
| first_indexed | 2024-12-18T00:58:07Z |
| format | Article |
| id | doaj.art-47ece596b47a45ea967d387b68b5a08a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-18T00:58:07Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-47ece596b47a45ea967d387b68b5a08a2022-12-21T21:26:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-10-011210.3389/fimmu.2021.774966774966Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula TreatmentLibing Zhu0Libing Zhu1Yuning Wu2Chenglong Lin3Lin Tang4Bin Yu5Wenrong Wan6Jingxiu Xuan7Yanling Du8Zhangran Chen9Wei Liang10Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Traditional Chinese Medicine, Xiamen University Hospital, Xiamen, ChinaSchool of Mathematical Sciences, Xiamen University, Xiamen, ChinaDepartment of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Otorhinolaryngology, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, ChinaDepartment of Otorhinolaryngology, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, ChinaInternal Medicine Department of Traditional Chinese Medicine, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, ChinaLaboratory of Rheumatology and Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Acupuncture and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaInstitute for Microbial Ecology, School of Medicine, Xiamen University, Xiamen, ChinaSchool of Mathematical Sciences, Xiamen University, Xiamen, ChinaA mixed Chinese herbal formula, Xiao-Qing-Long-Decoction (XQLD), may contribute to sustained remission in allergic rhinitis (AR), but it is unknown which factors determine such long-term effect. Here, we aimed to identify bacterial signatures associated with sustained remission. To this end, samples from AR patients at four different times were analyzed to compare the dynamic bacterial community and structure shifts. Diversity indices Chao1 showed significant difference across different time (p<0.05), and the Kruskal-Wallis test identified that Dialister (OTU_31), Roseburia (OTU_36), Bacteroides (OTU_22), Bacteroides (OTU_2040), and Prevotella_9 (OTU_5) were the significant differential bacterial taxa (p<0.05). These distinctive genera were significantly associated with the change of AR clinical indices and the predicted functional pathways such as PPAR signaling pathway, peroxisome, and citrate cycle (TCA cycle) (p<0.05), indicating that they may be important bacterial signatures involving in the sustained remission in AR (p<0.05). Besides, lower Firmicutes/Bacteroidetes (F/B) ratio at 6 months follow-up may also contribute to the long-term remission of AR. No seriously adverse events and safety concerns were observed in this study. In conclusion, XQLD is a meaningful, long-term efficient and safe medication for AR treatment. The underlying mechanisms of sustained remission in AR after XQLD treatment may be associated with the dynamic alteration of featured gut bacteria taxa.https://www.frontiersin.org/articles/10.3389/fimmu.2021.774966/fullXiao-Qing-Long-Decoctionallergic rhinitislong-term remissiongut microbiota16S rRNA |
| spellingShingle | Libing Zhu Libing Zhu Yuning Wu Chenglong Lin Lin Tang Bin Yu Wenrong Wan Jingxiu Xuan Yanling Du Zhangran Chen Wei Liang Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment Frontiers in Immunology Xiao-Qing-Long-Decoction allergic rhinitis long-term remission gut microbiota 16S rRNA |
| title | Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment |
| title_full | Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment |
| title_fullStr | Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment |
| title_full_unstemmed | Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment |
| title_short | Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment |
| title_sort | dynamic microbial shifts and signatures of long term remission in allergic rhinitis after an herbal formula treatment |
| topic | Xiao-Qing-Long-Decoction allergic rhinitis long-term remission gut microbiota 16S rRNA |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.774966/full |
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