Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars

Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars

Hypertrophic scars (HSs) and keloids are histologically characterized by excessive extracellular matrix (ECM) deposition. ECM deposition depends on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteases (TIMPs). TIMP-1 has been linked to ECM degradation and is...

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Bibliographic Details
Main Authors: Masayo Aoki, Noriko M. Matsumoto, Teruyuki Dohi, Hiroaki Kuwahawa, Satoshi Akaishi, Yuri Okubo, Rei Ogawa, Hirofumi Yamamoto, Kazuaki Takabe
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
abnormal scar
keloid
hyprtrophic scar
siRNA
nanoparticle
TIMP
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302341

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