Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load
Water depleted of heavy isotopes, such as <sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub> (HIDW), has shown numerous biological/health effects <i>in vitro</i>, <i>in vivo</i>, and in epidemiological studies. Major obse...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Sports |
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| Online Access: | https://www.mdpi.com/2075-4663/9/8/110 |
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| author | Zaira Kharaeva Tamara Hokonova Jannet Elmurzaeva Irlana Dzamihova Wolfgang Mayer Chiara De Luca Ilya Trakhtman Liudmila Korkina |
| author_facet | Zaira Kharaeva Tamara Hokonova Jannet Elmurzaeva Irlana Dzamihova Wolfgang Mayer Chiara De Luca Ilya Trakhtman Liudmila Korkina |
| author_sort | Zaira Kharaeva |
| collection | DOAJ |
| description | Water depleted of heavy isotopes, such as <sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub> (HIDW), has shown numerous biological/health effects <i>in vitro</i>, <i>in vivo</i>, and in epidemiological studies. Major observations were related to cell growth/differentiation, immune/nervous system responses, endurance/adaptation, mitochondrial electron transfer, energy production, glucose metabolism, etc. No human studies to confirm physiological, metabolic, and immune responses to the consumption of HIDW have been performed. A placebo-controlled study on healthy volunteers (n = 50) under fitness load who consumed 1.5 L HIDW (58 ppm <sup>2</sup>H and 1780 ppm <sup>18</sup>O) or normal water for 60 days was carried out. Plasma content of <sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>, markers of energy, lipid, and glucose metabolism, anthropometric, cardio-vascular, oxidant/antioxidant, and immunological parameters were determined. Significant decrease in plasma heavy isotopes in the group consuming HIDW was observed in concomitance with an increase in ATP, insulin, and LDH, and diminished plasma lactate. Several anthropometric and cardio-vascular parameters were improved as compared to placebo group. Lipid markers demonstrated antiatherogenic effects, while oxidant/antioxidant parameters revealed HIDW-induced hormesis. Antibacterial/antiviral immunity was remarkably higher in HIDW <i>versus</i> placebo group. <b>Conclusions</b>: HIDW consumption by humans under fitness load could be a valid approach to improve their adaptation/recovery through several mechanisms. |
| first_indexed | 2024-03-10T08:23:19Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4663 |
| language | English |
| last_indexed | 2024-03-10T08:23:19Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sports |
| spelling | doaj.art-47ee0c4a40ec45c0a5c02c1a8bfc239e2023-11-22T09:45:14ZengMDPI AGSports2075-46632021-08-019811010.3390/sports9080110Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness LoadZaira Kharaeva0Tamara Hokonova1Jannet Elmurzaeva2Irlana Dzamihova3Wolfgang Mayer4Chiara De Luca5Ilya Trakhtman6Liudmila Korkina7Department of Microbiology, Virology, and Immunology, Kabardino-Balkar Berbekov’s State University, 176 Chernishevskogo St., 360000 Nal’chik, RussiaDepartment of Microbiology, Virology, and Immunology, Kabardino-Balkar Berbekov’s State University, 176 Chernishevskogo St., 360000 Nal’chik, RussiaDepartment of Microbiology, Virology, and Immunology, Kabardino-Balkar Berbekov’s State University, 176 Chernishevskogo St., 360000 Nal’chik, RussiaFitness Centre “S-Club”, 36 Kuliev Pr., 360030 Nal’chik, RussiaR&D Department, MEDENA AG, 16 Industriestrasse, CH-8910 Affoltern-am-Albis, SwitzerlandR&D Department, MEDENA AG, 16 Industriestrasse, CH-8910 Affoltern-am-Albis, SwitzerlandR&D Department, Swiss DEKOTRA GmbH, 549 Badenerstrasse, CH-8048 Zurich, SwitzerlandCentre of Innovative Biotechnological Investigations Nanolab (CIBI-NANOLAB), 197 Vernadskiy Pr., 119571 Moscow, RussiaWater depleted of heavy isotopes, such as <sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub> (HIDW), has shown numerous biological/health effects <i>in vitro</i>, <i>in vivo</i>, and in epidemiological studies. Major observations were related to cell growth/differentiation, immune/nervous system responses, endurance/adaptation, mitochondrial electron transfer, energy production, glucose metabolism, etc. No human studies to confirm physiological, metabolic, and immune responses to the consumption of HIDW have been performed. A placebo-controlled study on healthy volunteers (n = 50) under fitness load who consumed 1.5 L HIDW (58 ppm <sup>2</sup>H and 1780 ppm <sup>18</sup>O) or normal water for 60 days was carried out. Plasma content of <sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>, markers of energy, lipid, and glucose metabolism, anthropometric, cardio-vascular, oxidant/antioxidant, and immunological parameters were determined. Significant decrease in plasma heavy isotopes in the group consuming HIDW was observed in concomitance with an increase in ATP, insulin, and LDH, and diminished plasma lactate. Several anthropometric and cardio-vascular parameters were improved as compared to placebo group. Lipid markers demonstrated antiatherogenic effects, while oxidant/antioxidant parameters revealed HIDW-induced hormesis. Antibacterial/antiviral immunity was remarkably higher in HIDW <i>versus</i> placebo group. <b>Conclusions</b>: HIDW consumption by humans under fitness load could be a valid approach to improve their adaptation/recovery through several mechanisms.https://www.mdpi.com/2075-4663/9/8/110heavy isotopes depleted waterhormesisredox statuspro-/anti-inflammatory cytokinesrecovery timeglucose metabolism |
| spellingShingle | Zaira Kharaeva Tamara Hokonova Jannet Elmurzaeva Irlana Dzamihova Wolfgang Mayer Chiara De Luca Ilya Trakhtman Liudmila Korkina Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load Sports heavy isotopes depleted water hormesis redox status pro-/anti-inflammatory cytokines recovery time glucose metabolism |
| title | Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
| title_full | Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
| title_fullStr | Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
| title_full_unstemmed | Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
| title_short | Effects of Heavy Isotopes (<sup>2</sup>H<sub>1</sub> and <sup>18</sup>O<sub>16</sub>) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
| title_sort | effects of heavy isotopes sup 2 sup h sub 1 sub and sup 18 sup o sub 16 sub depleted water con sumption on physical recovery and metabolic and immunological parameters of healthy volunteers under regular fitness load |
| topic | heavy isotopes depleted water hormesis redox status pro-/anti-inflammatory cytokines recovery time glucose metabolism |
| url | https://www.mdpi.com/2075-4663/9/8/110 |
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