Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2
SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. T...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/980 |
| _version_ | 1797532719141355520 |
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| author | Christina Chuong Christine M. DuChane Emily M. Webb Pallavi Rai Jeffrey M. Marano Chad M. Bernier Joseph S. Merola James Weger-Lucarelli |
| author_facet | Christina Chuong Christine M. DuChane Emily M. Webb Pallavi Rai Jeffrey M. Marano Chad M. Bernier Joseph S. Merola James Weger-Lucarelli |
| author_sort | Christina Chuong |
| collection | DOAJ |
| description | SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl<sub>2</sub> (complex 2) and Cp*Rh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity. |
| first_indexed | 2024-03-10T11:03:18Z |
| format | Article |
| id | doaj.art-47ee4cc5bb9343abba7322dd930996b4 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:03:18Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-47ee4cc5bb9343abba7322dd930996b42023-11-21T21:19:07ZengMDPI AGViruses1999-49152021-05-0113698010.3390/v13060980Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2Christina Chuong0Christine M. DuChane1Emily M. Webb2Pallavi Rai3Jeffrey M. Marano4Chad M. Bernier5Joseph S. Merola6James Weger-Lucarelli7Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USADepartment of Chemistry, Virginia Tech, Blacksburg, VA 24061, USADepartment of Entomology, Virginia Tech, Blacksburg, VA 24061, USADepartment of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USADepartment of Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061, USADepartment of Chemistry, Virginia Tech, Blacksburg, VA 24061, USADepartment of Chemistry, Virginia Tech, Blacksburg, VA 24061, USADepartment of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USASARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl<sub>2</sub> (complex 2) and Cp*Rh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity.https://www.mdpi.com/1999-4915/13/6/980SARS-CoV-2COVID-19organometallicsmetallodrugsantiviralvirucidal |
| spellingShingle | Christina Chuong Christine M. DuChane Emily M. Webb Pallavi Rai Jeffrey M. Marano Chad M. Bernier Joseph S. Merola James Weger-Lucarelli Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 Viruses SARS-CoV-2 COVID-19 organometallics metallodrugs antiviral virucidal |
| title | Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 |
| title_full | Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 |
| title_fullStr | Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 |
| title_full_unstemmed | Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 |
| title_short | Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 |
| title_sort | noble metal organometallic complexes display antiviral activity against sars cov 2 |
| topic | SARS-CoV-2 COVID-19 organometallics metallodrugs antiviral virucidal |
| url | https://www.mdpi.com/1999-4915/13/6/980 |
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