Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses
Abstract Fritillaria naturally grows in the temperate region of Northern Hemisphere and mainly distributes in Central Asia, Mediterranean region, and North America. The dried bulbs from a dozen species of this genus have been usually used as herbal medicine, named Beimu in China. Beimu had rich sour...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Chinese Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13020-021-00450-1 |
| _version_ | 1819139188617904128 |
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| author | Ye Wang Hongping Hou Qiang Ren Haoyu Hu Tiechui Yang Xiwen Li |
| author_facet | Ye Wang Hongping Hou Qiang Ren Haoyu Hu Tiechui Yang Xiwen Li |
| author_sort | Ye Wang |
| collection | DOAJ |
| description | Abstract Fritillaria naturally grows in the temperate region of Northern Hemisphere and mainly distributes in Central Asia, Mediterranean region, and North America. The dried bulbs from a dozen species of this genus have been usually used as herbal medicine, named Beimu in China. Beimu had rich sources of phytochemicals and have extensively applied to respiratory diseases including coronavirus disease (COVID-19). Fritillaria species have alkaloids that act as the main active components that contribute multiple biological activities, including anti-tussive, expectorant, and anti-asthmatic effects, especially against certain respiratory diseases. Other compounds (terpenoids, steroidal saponins, and phenylpropanoids) have also been identified in species of Fritillaria. In this review, readers will discover a brief summary of traditional uses and a comprehensive description of the chemical profiles, biological properties, and analytical techniques used for quality control. In general, the detailed summary reveals 293 specialized metabolites that have been isolated and analyzed in Fritillaria species. This review may provide a scientific basis for the chemical ecology and metabolomics in which compound identification of certain species remains a limiting step. |
| first_indexed | 2024-12-22T11:18:42Z |
| format | Article |
| id | doaj.art-47ee9267635f4bb4b20d82fbc278c941 |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-12-22T11:18:42Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-47ee9267635f4bb4b20d82fbc278c9412022-12-21T18:27:56ZengBMCChinese Medicine1749-85462021-05-0116114110.1186/s13020-021-00450-1Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analysesYe Wang0Hongping Hou1Qiang Ren2Haoyu Hu3Tiechui Yang4Xiwen Li5Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesInstitute of Chinese Materia Medica, China Academy of Chinese Medical SciencesDepartment of Pharmacy, Jining Medical UniversityInstitute of Chinese Materia Medica, China Academy of Chinese Medical SciencesNin Jiom Medicine Manufactory (Hong Kong) LimitedInstitute of Chinese Materia Medica, China Academy of Chinese Medical SciencesAbstract Fritillaria naturally grows in the temperate region of Northern Hemisphere and mainly distributes in Central Asia, Mediterranean region, and North America. The dried bulbs from a dozen species of this genus have been usually used as herbal medicine, named Beimu in China. Beimu had rich sources of phytochemicals and have extensively applied to respiratory diseases including coronavirus disease (COVID-19). Fritillaria species have alkaloids that act as the main active components that contribute multiple biological activities, including anti-tussive, expectorant, and anti-asthmatic effects, especially against certain respiratory diseases. Other compounds (terpenoids, steroidal saponins, and phenylpropanoids) have also been identified in species of Fritillaria. In this review, readers will discover a brief summary of traditional uses and a comprehensive description of the chemical profiles, biological properties, and analytical techniques used for quality control. In general, the detailed summary reveals 293 specialized metabolites that have been isolated and analyzed in Fritillaria species. This review may provide a scientific basis for the chemical ecology and metabolomics in which compound identification of certain species remains a limiting step.https://doi.org/10.1186/s13020-021-00450-1FritillariaAlkaloidsChemical componentsEthnopharmacologyRespiratory disease |
| spellingShingle | Ye Wang Hongping Hou Qiang Ren Haoyu Hu Tiechui Yang Xiwen Li Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses Chinese Medicine Fritillaria Alkaloids Chemical components Ethnopharmacology Respiratory disease |
| title | Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses |
| title_full | Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses |
| title_fullStr | Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses |
| title_full_unstemmed | Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses |
| title_short | Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses |
| title_sort | natural drug sources for respiratory diseases from fritillaria chemical and biological analyses |
| topic | Fritillaria Alkaloids Chemical components Ethnopharmacology Respiratory disease |
| url | https://doi.org/10.1186/s13020-021-00450-1 |
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