Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study
The pulsatile flow rate (PFR) in the cerebral artery system and shunt ratios in bifurcated arteries are two patient-specific parameters that may affect the hemodynamic characteristics in the pathobiology of cerebral aneurysms, which needs to be identified comprehensively. Accordingly, a systematic s...
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MDPI AG
2022-07-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/7/326 |
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| author | Hang Yi Mark Johnson Luke C. Bramlage Bryan Ludwig Zifeng Yang |
| author_facet | Hang Yi Mark Johnson Luke C. Bramlage Bryan Ludwig Zifeng Yang |
| author_sort | Hang Yi |
| collection | DOAJ |
| description | The pulsatile flow rate (PFR) in the cerebral artery system and shunt ratios in bifurcated arteries are two patient-specific parameters that may affect the hemodynamic characteristics in the pathobiology of cerebral aneurysms, which needs to be identified comprehensively. Accordingly, a systematic study was employed to study the effects of pulsatile flow rate (i.e., PFR−I, PFR−II, and PFR−III) and shunt ratio (i.e., 75:25 and 64:36) in bifurcated distal arteries, and transient cardiac pulsatile waveform on hemodynamic patterns in two internal carotid artery sidewall aneurysm models using computational fluid dynamics (CFD) modeling. Numerical results indicate that larger PFRs can cause higher wall shear stress (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>W</mi><mi>S</mi><mi>S</mi></mrow></semantics></math></inline-formula>) in some local regions of the aneurysmal dome that may increase the probability of small/secondary aneurysm generation than under smaller PFRs. The low <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>W</mi><mi>S</mi><mi>S</mi></mrow></semantics></math></inline-formula> and relatively high oscillatory shear index (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>O</mi><mi>S</mi><mi>I</mi></mrow></semantics></math></inline-formula>) could appear under a smaller PFR, increasing the potential risk of aneurysmal sac growth and rupture. However, the variances in PFRs and bifurcated shunt ratios have rare impacts on the time-average pressure (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>T</mi><mi>A</mi><mi>P</mi></mrow></semantics></math></inline-formula>) distributions on the aneurysmal sac, although a higher PFR can contribute more to the pressure increase in the ICASA−1 dome due to the relatively stronger impingement by the redirected bloodstream than in ICASA−2. CFD simulations also show that the variances of shunt ratios in bifurcated distal arteries have rare impacts on the hemodynamic characteristics in the sacs, mainly because the bifurcated location is not close enough to the sac in present models. Furthermore, it has been found that the vortex location plays a major role in the temporal and spatial distribution of the WSS on the luminal wall, varying significantly with the cardiac period. |
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| spelling | doaj.art-47ef4776b0794feba37b90afa56e41702023-12-01T21:54:02ZengMDPI AGBioengineering2306-53542022-07-019732610.3390/bioengineering9070326Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical StudyHang Yi0Mark Johnson1Luke C. Bramlage2Bryan Ludwig3Zifeng Yang4Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH 45435, USADepartment of Mechanical and Materials Engineering, Wright State University, Dayton, OH 45435, USADivision of NeuroInterventional Surgery, Department of Neurology, Wright State University/Premier Health—Clinical Neuroscience Institute, 30E. Apple St., Dayton, OH 45409, USADivision of NeuroInterventional Surgery, Department of Neurology, Wright State University/Premier Health—Clinical Neuroscience Institute, 30E. Apple St., Dayton, OH 45409, USADepartment of Mechanical and Materials Engineering, Wright State University, Dayton, OH 45435, USAThe pulsatile flow rate (PFR) in the cerebral artery system and shunt ratios in bifurcated arteries are two patient-specific parameters that may affect the hemodynamic characteristics in the pathobiology of cerebral aneurysms, which needs to be identified comprehensively. Accordingly, a systematic study was employed to study the effects of pulsatile flow rate (i.e., PFR−I, PFR−II, and PFR−III) and shunt ratio (i.e., 75:25 and 64:36) in bifurcated distal arteries, and transient cardiac pulsatile waveform on hemodynamic patterns in two internal carotid artery sidewall aneurysm models using computational fluid dynamics (CFD) modeling. Numerical results indicate that larger PFRs can cause higher wall shear stress (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>W</mi><mi>S</mi><mi>S</mi></mrow></semantics></math></inline-formula>) in some local regions of the aneurysmal dome that may increase the probability of small/secondary aneurysm generation than under smaller PFRs. The low <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>W</mi><mi>S</mi><mi>S</mi></mrow></semantics></math></inline-formula> and relatively high oscillatory shear index (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>O</mi><mi>S</mi><mi>I</mi></mrow></semantics></math></inline-formula>) could appear under a smaller PFR, increasing the potential risk of aneurysmal sac growth and rupture. However, the variances in PFRs and bifurcated shunt ratios have rare impacts on the time-average pressure (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>T</mi><mi>A</mi><mi>P</mi></mrow></semantics></math></inline-formula>) distributions on the aneurysmal sac, although a higher PFR can contribute more to the pressure increase in the ICASA−1 dome due to the relatively stronger impingement by the redirected bloodstream than in ICASA−2. CFD simulations also show that the variances of shunt ratios in bifurcated distal arteries have rare impacts on the hemodynamic characteristics in the sacs, mainly because the bifurcated location is not close enough to the sac in present models. Furthermore, it has been found that the vortex location plays a major role in the temporal and spatial distribution of the WSS on the luminal wall, varying significantly with the cardiac period.https://www.mdpi.com/2306-5354/9/7/326internal carotid artery sidewall aneurysm (ICASA)hemodynamic behaviorscomputational fluid dynamics (CFD)pulsatile flow rate (PFR)bifurcated shunt ratiowall shear stress (<i>WSS</i>) |
| spellingShingle | Hang Yi Mark Johnson Luke C. Bramlage Bryan Ludwig Zifeng Yang Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study Bioengineering internal carotid artery sidewall aneurysm (ICASA) hemodynamic behaviors computational fluid dynamics (CFD) pulsatile flow rate (PFR) bifurcated shunt ratio wall shear stress (<i>WSS</i>) |
| title | Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study |
| title_full | Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study |
| title_fullStr | Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study |
| title_full_unstemmed | Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study |
| title_short | Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study |
| title_sort | effects of pulsatile flow rate and shunt ratio in bifurcated distal arteries on hemodynamic characteristics involved in two patient specific internal carotid artery sidewall aneurysms a numerical study |
| topic | internal carotid artery sidewall aneurysm (ICASA) hemodynamic behaviors computational fluid dynamics (CFD) pulsatile flow rate (PFR) bifurcated shunt ratio wall shear stress (<i>WSS</i>) |
| url | https://www.mdpi.com/2306-5354/9/7/326 |
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