Histopathological features of mucosa atrophy in atrophic body gastritis
ABSTRACT Introduction: Gastric mucosa atrophy became a major issue in gastric pathology because of its connection with risk lesions for gastric cancer. Although gastric atrophy is frequently associated with different diseases, it has been included in many studies simply as a generic pathological co...
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Sociedade Brasileira de Patologia Clínica
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000100050&lng=en&tlng=en |
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| author | Alfredo J. A. Barbosa Marcela S. Boldt Carolinne B. Rodrigues Camila S. C. Silva Hulie M. Ferreira Rivelle D. Pereira |
| author_facet | Alfredo J. A. Barbosa Marcela S. Boldt Carolinne B. Rodrigues Camila S. C. Silva Hulie M. Ferreira Rivelle D. Pereira |
| author_sort | Alfredo J. A. Barbosa |
| collection | DOAJ |
| description | ABSTRACT Introduction: Gastric mucosa atrophy became a major issue in gastric pathology because of its connection with risk lesions for gastric cancer. Although gastric atrophy is frequently associated with different diseases, it has been included in many studies simply as a generic pathological condition, and different causes of gastric atrophy are omitted. Objective: To study the histopathological features of gastric mucosa atrophy inH. pylori- negative patients with atrophic body gastritis (ABG). Material and methods: Consecutive cases of patients diagnosed with ABG, and presenting normal or just lightly inflamed antral mucosa, were studied. Patients with gastrointestinal cancer and those with history of prior gastrointestinal surgery were excluded. The presence of intestinal metaplasia and pseudoantral (PSA) metaplasia in atrophic body mucosa was assessed. Results: During the period of 2004-2006 a total of 7,309 patients underwent gastroesophageal endoscopy with biopsies of the gastric mucosa; 3,556 (48.6%) were males, and 3,713 (51.4%) females. Among them, 105 had the diagnosis of ABG confirmed, with 32 (30.5%) males, and 73 (69.5%) females (p < 0.001). Intestinal metaplasia and/or PSA metaplasia were identified in all patients. As isolated lesions, PSA metaplasia was more frequent than intestinal metaplasia, respectively 42 (40%) vs. four (3.8%) cases. In most patients (56.2%) both types of metaplasia occurred simultaneously, and no differences were observed among genders (p = 0.67). Conclusion: Gastric mucosa atrophy in ABG shows distinctive histopathological features which should be considered in studies on the relationship between gastric mucosa atrophy and gastric cancer. |
| first_indexed | 2024-12-12T02:58:55Z |
| format | Article |
| id | doaj.art-47f0d50a7dd64a0fa8f8b2463b214223 |
| institution | Directory Open Access Journal |
| issn | 1676-2444 1678-4774 |
| language | English |
| last_indexed | 2024-12-12T02:58:55Z |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-47f0d50a7dd64a0fa8f8b2463b2142232022-12-22T00:40:41ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1676-24441678-4774521505410.5935/1676-2444.20160006S1676-24442016000100050Histopathological features of mucosa atrophy in atrophic body gastritisAlfredo J. A. BarbosaMarcela S. BoldtCarolinne B. RodriguesCamila S. C. SilvaHulie M. FerreiraRivelle D. PereiraABSTRACT Introduction: Gastric mucosa atrophy became a major issue in gastric pathology because of its connection with risk lesions for gastric cancer. Although gastric atrophy is frequently associated with different diseases, it has been included in many studies simply as a generic pathological condition, and different causes of gastric atrophy are omitted. Objective: To study the histopathological features of gastric mucosa atrophy inH. pylori- negative patients with atrophic body gastritis (ABG). Material and methods: Consecutive cases of patients diagnosed with ABG, and presenting normal or just lightly inflamed antral mucosa, were studied. Patients with gastrointestinal cancer and those with history of prior gastrointestinal surgery were excluded. The presence of intestinal metaplasia and pseudoantral (PSA) metaplasia in atrophic body mucosa was assessed. Results: During the period of 2004-2006 a total of 7,309 patients underwent gastroesophageal endoscopy with biopsies of the gastric mucosa; 3,556 (48.6%) were males, and 3,713 (51.4%) females. Among them, 105 had the diagnosis of ABG confirmed, with 32 (30.5%) males, and 73 (69.5%) females (p < 0.001). Intestinal metaplasia and/or PSA metaplasia were identified in all patients. As isolated lesions, PSA metaplasia was more frequent than intestinal metaplasia, respectively 42 (40%) vs. four (3.8%) cases. In most patients (56.2%) both types of metaplasia occurred simultaneously, and no differences were observed among genders (p = 0.67). Conclusion: Gastric mucosa atrophy in ABG shows distinctive histopathological features which should be considered in studies on the relationship between gastric mucosa atrophy and gastric cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000100050&lng=en&tlng=engastritegastrite atróficaestômagogastropatias |
| spellingShingle | Alfredo J. A. Barbosa Marcela S. Boldt Carolinne B. Rodrigues Camila S. C. Silva Hulie M. Ferreira Rivelle D. Pereira Histopathological features of mucosa atrophy in atrophic body gastritis Jornal Brasileiro de Patologia e Medicina Laboratorial gastrite gastrite atrófica estômago gastropatias |
| title | Histopathological features of mucosa atrophy in atrophic body gastritis |
| title_full | Histopathological features of mucosa atrophy in atrophic body gastritis |
| title_fullStr | Histopathological features of mucosa atrophy in atrophic body gastritis |
| title_full_unstemmed | Histopathological features of mucosa atrophy in atrophic body gastritis |
| title_short | Histopathological features of mucosa atrophy in atrophic body gastritis |
| title_sort | histopathological features of mucosa atrophy in atrophic body gastritis |
| topic | gastrite gastrite atrófica estômago gastropatias |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000100050&lng=en&tlng=en |
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