Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the sources of this variation are incompletely understood. Here, we have studied the...
Main Authors: | Ganna Reint, Zhuokun Li, Kornel Labun, Salla Keskitalo, Inkeri Soppa, Katariina Mamia, Eero Tolo, Monika Szymanska, Leonardo A Meza-Zepeda, Susanne Lorenz, Artur Cieslar-Pobuda, Xian Hu, Diana L Bordin, Judith Staerk, Eivind Valen, Bernhard Schmierer, Markku Varjosalo, Jussi Taipale, Emma Haapaniemi |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/75415 |
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