A Method for Using Cell-Penetrating Peptides for Loading Plasmid DNA into Secreted Extracellular Vesicles

A Method for Using Cell-Penetrating Peptides for Loading Plasmid DNA into Secreted Extracellular Vesicles

The low bioavailability and high toxicity of plasmid DNA (pDNA)-based therapeutics pose challenges for their in vivo application. Extracellular vesicles (EVs) have great potential to overcome these limitations, as they are biocompatible native cargo carriers. Various methods for loading pDNA into EV...

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Chi tiết về thư mục
Những tác giả chính: Jekaterina Nebogatova, Heleri Heike Härk, Anett Puskar, Ly Porosk, Paolo Guazzi, Moataz Dowaidar, Ülo Langel, Kaido Kurrikoff
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: MDPI AG 2023-12-01
Loạt:Biomolecules
Những chủ đề:
extracellular vesicles
gene therapy
nucleic acid therapeutics
drug delivery system
cell-penetrating peptides
Truy cập trực tuyến:https://www.mdpi.com/2218-273X/13/12/1751

Internet

https://www.mdpi.com/2218-273X/13/12/1751

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