The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity Model
The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following...
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2022-02-01
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author | Aline Boveto Santamarina Ruan Carlos Macêdo Moraes Victor Nehmi Filho Gilson Masahiro Murata Jéssica Alves de Freitas Danielle Araujo de Miranda Anderson Romério Azevedo Cerqueira Soraia Katia Pereira Costa Ana Flávia Fernandes Ferreira Luiz Roberto Britto Juliana Alves de Camargo Daniela Rodrigues de Oliveira Flavia Neto de Jesus José Pinhata Otoch Ana Flávia Marçal Pessoa |
author_facet | Aline Boveto Santamarina Ruan Carlos Macêdo Moraes Victor Nehmi Filho Gilson Masahiro Murata Jéssica Alves de Freitas Danielle Araujo de Miranda Anderson Romério Azevedo Cerqueira Soraia Katia Pereira Costa Ana Flávia Fernandes Ferreira Luiz Roberto Britto Juliana Alves de Camargo Daniela Rodrigues de Oliveira Flavia Neto de Jesus José Pinhata Otoch Ana Flávia Marçal Pessoa |
author_sort | Aline Boveto Santamarina |
collection | DOAJ |
description | The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four weeks of the diet (28 consecutive days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene expression in these groups of mice. After four weeks of supplementation, only the new nutraceutical group (HFD + Supplemented) experienced reduced fasting glycemia, insulin, HOMA index, HOMA-β, dyslipidemia, ectopic fat deposition, and hepatic fibrosis levels. Additionally, the PPARγ coactivator 1 α (<i>Pgc-1α</i>), interleukin-6 <i>(Il-6),</i> and interleukin-10 <i>(Il-10</i>) gene expression were augmented, while hepatic steatosis decreased and liver parenchyma was recovered. The glutathione-S-transferase activity status was found to be modulated by the supplement. We discovered that the new nutraceutical was able to improve insulin resistance and hepatic steatosis mainly by regulating <i>IL-6, IL-10</i>, and <i>Pgc-1α</i> gene expression. |
first_indexed | 2024-03-09T13:52:53Z |
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institution | Directory Open Access Journal |
issn | 2076-3921 |
language | English |
last_indexed | 2024-03-09T13:52:53Z |
publishDate | 2022-02-01 |
publisher | MDPI AG |
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series | Antioxidants |
spelling | doaj.art-47f4f913cc024b19ac4e30ca3f7f9aaf2023-11-30T20:47:25ZengMDPI AGAntioxidants2076-39212022-02-0111344710.3390/antiox11030447The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity ModelAline Boveto Santamarina0Ruan Carlos Macêdo Moraes1Victor Nehmi Filho2Gilson Masahiro Murata3Jéssica Alves de Freitas4Danielle Araujo de Miranda5Anderson Romério Azevedo Cerqueira6Soraia Katia Pereira Costa7Ana Flávia Fernandes Ferreira8Luiz Roberto Britto9Juliana Alves de Camargo10Daniela Rodrigues de Oliveira11Flavia Neto de Jesus12José Pinhata Otoch13Ana Flávia Marçal Pessoa14Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos 11015-020, SP, BrazilNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilLaboratory of Medical Investigation (LIM-29), Clinic Medical Department, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilDepartment of Physiology, Escola Paulista de Medicina/Universidade Federal de São Paulo, São Paulo 04023-062, SP, BrazilDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, BrazilDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, BrazilDepartamento de Fisiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, BrazilDepartamento de Fisiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, BrazilLaboratory of Medical Investigation (LIM-55), Urology Department, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine Alberta, Calgary, AB T2N 1N4, CanadaNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, BrazilThe use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four weeks of the diet (28 consecutive days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene expression in these groups of mice. After four weeks of supplementation, only the new nutraceutical group (HFD + Supplemented) experienced reduced fasting glycemia, insulin, HOMA index, HOMA-β, dyslipidemia, ectopic fat deposition, and hepatic fibrosis levels. Additionally, the PPARγ coactivator 1 α (<i>Pgc-1α</i>), interleukin-6 <i>(Il-6),</i> and interleukin-10 <i>(Il-10</i>) gene expression were augmented, while hepatic steatosis decreased and liver parenchyma was recovered. The glutathione-S-transferase activity status was found to be modulated by the supplement. We discovered that the new nutraceutical was able to improve insulin resistance and hepatic steatosis mainly by regulating <i>IL-6, IL-10</i>, and <i>Pgc-1α</i> gene expression.https://www.mdpi.com/2076-3921/11/3/447nutraceuticalsilymarinprebioticyeast β-glucanmineralsobesity |
spellingShingle | Aline Boveto Santamarina Ruan Carlos Macêdo Moraes Victor Nehmi Filho Gilson Masahiro Murata Jéssica Alves de Freitas Danielle Araujo de Miranda Anderson Romério Azevedo Cerqueira Soraia Katia Pereira Costa Ana Flávia Fernandes Ferreira Luiz Roberto Britto Juliana Alves de Camargo Daniela Rodrigues de Oliveira Flavia Neto de Jesus José Pinhata Otoch Ana Flávia Marçal Pessoa The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity Model Antioxidants nutraceutical silymarin prebiotic yeast β-glucan minerals obesity |
title | The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity Model |
title_full | The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity Model |
title_fullStr | The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity Model |
title_full_unstemmed | The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity Model |
title_short | The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and <i>Silybum marianum</i> (Silymarin) for Recovering Metabolic Homeostasis via <i>Pgc-1α</i>, <i>Il-6</i>, and <i>Il-10</i> Gene Expression in a Type-2 Diabetes Obesity Model |
title_sort | symbiotic effect of a new nutraceutical with yeast β glucan prebiotics minerals and i silybum marianum i silymarin for recovering metabolic homeostasis via i pgc 1α i i il 6 i and i il 10 i gene expression in a type 2 diabetes obesity model |
topic | nutraceutical silymarin prebiotic yeast β-glucan minerals obesity |
url | https://www.mdpi.com/2076-3921/11/3/447 |
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