Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen Compositions
The creation of cancer vaccines is a constant priority for research and biotechnology. Therefore, the emergence of any new technology in this field is a significant event, especially because previous technologies have not yielded results. Recently, the development of a cancer vaccine has been comple...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4401 |
| _version_ | 1797445869445840896 |
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| author | Petr G. Lokhov Steven Lichtenberg Elena E. Balashova |
| author_facet | Petr G. Lokhov Steven Lichtenberg Elena E. Balashova |
| author_sort | Petr G. Lokhov |
| collection | DOAJ |
| description | The creation of cancer vaccines is a constant priority for research and biotechnology. Therefore, the emergence of any new technology in this field is a significant event, especially because previous technologies have not yielded results. Recently, the development of a cancer vaccine has been complemented by a new proteomics technology platform that allows the creation of antigen compositions known as antigenic essences. Antigenic essence comprises a target fraction of cellular antigens, the composition of which is precisely controlled by peptide mass spectrometry and compared to the proteomic footprint of the target cells to ensure similarity. This proteomics platform offers potential for a massive upgrade of conventional cellular cancer vaccines. Antigenic essences have the same mechanism of action, but without the disadvantages, and with notable advantages such as precise targeting of the immune response, safety, controlled composition, improved immunogenicity, addressed MHC restriction, and extended range of vaccination doses. The present paper calls attention to this novel platform, stimulates discussion of the role of antigenic essence in vaccine development, and consolidates academic science with biotech capabilities. A brief description of the platform, list of cellular cancer vaccines suitable for the upgrade, main recommendations, limitations, and legal and ethical aspects of vaccine upgrade are reported here. |
| first_indexed | 2024-03-09T13:32:00Z |
| format | Article |
| id | doaj.art-47f662329934458aa0459ada37596111 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:32:00Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-47f662329934458aa0459ada375961112023-11-30T21:16:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238440110.3390/ijms23084401Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen CompositionsPetr G. Lokhov0Steven Lichtenberg1Elena E. Balashova2Biobohemia, Inc., 1 Broadway, 14th Floor, Cambridge, MA 02142, USABiobohemia, Inc., 1 Broadway, 14th Floor, Cambridge, MA 02142, USABiobohemia, Inc., 1 Broadway, 14th Floor, Cambridge, MA 02142, USAThe creation of cancer vaccines is a constant priority for research and biotechnology. Therefore, the emergence of any new technology in this field is a significant event, especially because previous technologies have not yielded results. Recently, the development of a cancer vaccine has been complemented by a new proteomics technology platform that allows the creation of antigen compositions known as antigenic essences. Antigenic essence comprises a target fraction of cellular antigens, the composition of which is precisely controlled by peptide mass spectrometry and compared to the proteomic footprint of the target cells to ensure similarity. This proteomics platform offers potential for a massive upgrade of conventional cellular cancer vaccines. Antigenic essences have the same mechanism of action, but without the disadvantages, and with notable advantages such as precise targeting of the immune response, safety, controlled composition, improved immunogenicity, addressed MHC restriction, and extended range of vaccination doses. The present paper calls attention to this novel platform, stimulates discussion of the role of antigenic essence in vaccine development, and consolidates academic science with biotech capabilities. A brief description of the platform, list of cellular cancer vaccines suitable for the upgrade, main recommendations, limitations, and legal and ethical aspects of vaccine upgrade are reported here.https://www.mdpi.com/1422-0067/23/8/4401antigenic essenceupgradecancer vaccinecell proteomic footprintmass spectrometryconsortium |
| spellingShingle | Petr G. Lokhov Steven Lichtenberg Elena E. Balashova Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen Compositions International Journal of Molecular Sciences antigenic essence upgrade cancer vaccine cell proteomic footprint mass spectrometry consortium |
| title | Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen Compositions |
| title_full | Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen Compositions |
| title_fullStr | Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen Compositions |
| title_full_unstemmed | Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen Compositions |
| title_short | Changing Landscape of Cancer Vaccines—Novel Proteomics Platform for New Antigen Compositions |
| title_sort | changing landscape of cancer vaccines novel proteomics platform for new antigen compositions |
| topic | antigenic essence upgrade cancer vaccine cell proteomic footprint mass spectrometry consortium |
| url | https://www.mdpi.com/1422-0067/23/8/4401 |
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