Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells
Spinal cord injury (SCI) is a result of a devastating injury to the central nervous system. Currently, there is no effective treatment available for these patients. The possible use of mesenchymal stem cell (MSC)-based treatment for SCI has been the focus of extensive investigations and is increasin...
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| Format: | Article |
| Language: | English |
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Korean Spinal Neurosurgery Society
2022-09-01
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| Series: | Neurospine |
| Subjects: | |
| Online Access: | http://e-neurospine.org/upload/pdf/ns-2244272-136.pdf |
| _version_ | 1797334726978043904 |
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| author | Yuan-huan Ma Qing-yue Liang Ying Ding Inbo Han Xiang Zeng |
| author_facet | Yuan-huan Ma Qing-yue Liang Ying Ding Inbo Han Xiang Zeng |
| author_sort | Yuan-huan Ma |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is a result of a devastating injury to the central nervous system. Currently, there is no effective treatment available for these patients. The possible use of mesenchymal stem cell (MSC)-based treatment for SCI has been the focus of extensive investigations and is increasingly moving from the bench to bedside. Both experimental observations and clinical studies have shown the safety and efficacy of MSCs in managing SCI. However, the exact mechanism by which MSCs contribute to the repair of the injured spinal cord remains to be elucidated. In this review, we aim to summarize current research findings about the role of MSCs in improving complex pathology after SCI. MSCs exert a multimodal repair mechanism targeting multiple events in the secondary injury cascade. Our recent results showing the perineurium-like differentiation of surviving MSCs in the injured spinal cord may further the understanding of the fate of transplanted MSCs. These findings provide fundamental support for the clinical use of MSCs in SCI patients. Under experimental conditions, combining novel physical, chemical, and biological approaches led to significant improvements in the therapeutic efficacy of MSCs. These findings hold promise for the future of cell-based clinical treatment of SCI. |
| first_indexed | 2024-03-08T08:25:22Z |
| format | Article |
| id | doaj.art-47f74b90610a4df9bc6eee278d0cdf4c |
| institution | Directory Open Access Journal |
| issn | 2586-6583 2586-6591 |
| language | English |
| last_indexed | 2024-03-08T08:25:22Z |
| publishDate | 2022-09-01 |
| publisher | Korean Spinal Neurosurgery Society |
| record_format | Article |
| series | Neurospine |
| spelling | doaj.art-47f74b90610a4df9bc6eee278d0cdf4c2024-02-02T04:45:26ZengKorean Spinal Neurosurgery SocietyNeurospine2586-65832586-65912022-09-0119361662910.14245/ns.2244272.1361292Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem CellsYuan-huan Ma0Qing-yue Liang1Ying Ding2Inbo Han3Xiang Zeng4 Guangzhou Institute of Clinical Medicine, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, Guangdong Province, China Department of Clinical Nutrition, Chengdu 7 th People’s Hospital, Chengdu Medical College, Chengdu, Sichuan Province, China Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University,Guangzhou, Guangdong Province, China Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Korea National Institute of Stem Cell Clinical Research, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, ChinaSpinal cord injury (SCI) is a result of a devastating injury to the central nervous system. Currently, there is no effective treatment available for these patients. The possible use of mesenchymal stem cell (MSC)-based treatment for SCI has been the focus of extensive investigations and is increasingly moving from the bench to bedside. Both experimental observations and clinical studies have shown the safety and efficacy of MSCs in managing SCI. However, the exact mechanism by which MSCs contribute to the repair of the injured spinal cord remains to be elucidated. In this review, we aim to summarize current research findings about the role of MSCs in improving complex pathology after SCI. MSCs exert a multimodal repair mechanism targeting multiple events in the secondary injury cascade. Our recent results showing the perineurium-like differentiation of surviving MSCs in the injured spinal cord may further the understanding of the fate of transplanted MSCs. These findings provide fundamental support for the clinical use of MSCs in SCI patients. Under experimental conditions, combining novel physical, chemical, and biological approaches led to significant improvements in the therapeutic efficacy of MSCs. These findings hold promise for the future of cell-based clinical treatment of SCI.http://e-neurospine.org/upload/pdf/ns-2244272-136.pdfspinal cord injurymesenchymal stem cellsmultimodal repairperineuriumclinical trials |
| spellingShingle | Yuan-huan Ma Qing-yue Liang Ying Ding Inbo Han Xiang Zeng Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells Neurospine spinal cord injury mesenchymal stem cells multimodal repair perineurium clinical trials |
| title | Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells |
| title_full | Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells |
| title_fullStr | Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells |
| title_full_unstemmed | Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells |
| title_short | Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells |
| title_sort | multimodal repair of spinal cord injury with mesenchymal stem cells |
| topic | spinal cord injury mesenchymal stem cells multimodal repair perineurium clinical trials |
| url | http://e-neurospine.org/upload/pdf/ns-2244272-136.pdf |
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