Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved]
Background: Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia. Methods: A total of 860 Mexicans (129 cases and 731 controls) between 18 and 25 years of a...
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F1000 Research Ltd
2021-09-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/10-217/v2 |
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| author | Juan Manuel Vargas-Morales Martha Guevara-Cruz Celia Aradillas-García Lilia G. Noriega Armando Tovar Jorge Alejandro Alegría-Torres |
| author_facet | Juan Manuel Vargas-Morales Martha Guevara-Cruz Celia Aradillas-García Lilia G. Noriega Armando Tovar Jorge Alejandro Alegría-Torres |
| author_sort | Juan Manuel Vargas-Morales |
| collection | DOAJ |
| description | Background: Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia. Methods: A total of 860 Mexicans (129 cases and 731 controls) between 18 and 25 years of age were genotyped for the ABCG2 (Q191K), SLC22A12 (517G>A), and XDH (518T>C) polymorphisms, as predisposing factors of hyperuricemia. Biochemical parameters were measured by spectrophotometry, while genetic polymorphisms were analyzed by real-time PCR. An analysis of the risk of hyperuricemia in relation to the variables studied was carried out using a logistic regression. Results: Male sex, being overweight or obese, having hypercholesterolemia or having hypertriglyceridemia were factors associated with hyperuricemia ( p ≤ 0.05). The ABCG2 polymorphism was associated with hyperuricemia (OR = 2.43, 95% CI: 1.41-4.17, p = 0.001) and hypercholesterolemia (OR = 4.89, 95% CI: 1.54-15.48, p = 0.003), employing a dominant model, but only in male participants. Conclusions: The ABCG2 (Q191K) polymorphism increases the risk of hyperuricemia and hypercholesterolemia in young Mexican males. |
| first_indexed | 2024-12-14T18:20:30Z |
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| id | doaj.art-47f7c5703cc44fccae8686c0909c32a5 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-14T18:20:30Z |
| publishDate | 2021-09-01 |
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| series | F1000Research |
| spelling | doaj.art-47f7c5703cc44fccae8686c0909c32a52022-12-21T22:52:05ZengF1000 Research LtdF1000Research2046-14022021-09-011010.12688/f1000research.46399.277844Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved]Juan Manuel Vargas-Morales0Martha Guevara-Cruz1Celia Aradillas-García2Lilia G. Noriega3Armando Tovar4Jorge Alejandro Alegría-Torres5Laboratorio de Análisis Clínicos, Facultad de Química, Universidad Autónoma de San Luis Potosí, San Luis Potosí, San Luis Potosí, 78210, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México, 14080, MexicoCentro de Investigación Aplicada en Ambiente y Salud, CIACYT-Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, San Luis Potosí, 78210, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México, 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México, 14080, MexicoDepartamento de Farmacia, Universidad de Guanajuato, Guanajuato, Guanajuato, 36050, MexicoBackground: Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia. Methods: A total of 860 Mexicans (129 cases and 731 controls) between 18 and 25 years of age were genotyped for the ABCG2 (Q191K), SLC22A12 (517G>A), and XDH (518T>C) polymorphisms, as predisposing factors of hyperuricemia. Biochemical parameters were measured by spectrophotometry, while genetic polymorphisms were analyzed by real-time PCR. An analysis of the risk of hyperuricemia in relation to the variables studied was carried out using a logistic regression. Results: Male sex, being overweight or obese, having hypercholesterolemia or having hypertriglyceridemia were factors associated with hyperuricemia ( p ≤ 0.05). The ABCG2 polymorphism was associated with hyperuricemia (OR = 2.43, 95% CI: 1.41-4.17, p = 0.001) and hypercholesterolemia (OR = 4.89, 95% CI: 1.54-15.48, p = 0.003), employing a dominant model, but only in male participants. Conclusions: The ABCG2 (Q191K) polymorphism increases the risk of hyperuricemia and hypercholesterolemia in young Mexican males.https://f1000research.com/articles/10-217/v2 |
| spellingShingle | Juan Manuel Vargas-Morales Martha Guevara-Cruz Celia Aradillas-García Lilia G. Noriega Armando Tovar Jorge Alejandro Alegría-Torres Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved] F1000Research |
| title | Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved] |
| title_full | Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved] |
| title_fullStr | Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved] |
| title_full_unstemmed | Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved] |
| title_short | Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults [version 2; peer review: 2 approved] |
| title_sort | polymorphisms of the genes abcg2 slc22a12 and xdh and their relation with hyperuricemia and hypercholesterolemia in mexican young adults version 2 peer review 2 approved |
| url | https://f1000research.com/articles/10-217/v2 |
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