Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study
Abstract Background Infections were the primary cause of death (34.3–55.5%) in patients with pemphigus. Skin was usually the origin of infections. The study aimed to explore features and associated factors of bacterial skin infections (BSIs) in inpatients with pemphigus. Methods One hundred and seve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12941-020-00388-6 |
| _version_ | 1818531616362856448 |
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| author | Furong Li Yejun Wu Wenjie Bian Lei Huang Xuejun Zhu Xixue Chen Mingyue Wang |
| author_facet | Furong Li Yejun Wu Wenjie Bian Lei Huang Xuejun Zhu Xixue Chen Mingyue Wang |
| author_sort | Furong Li |
| collection | DOAJ |
| description | Abstract Background Infections were the primary cause of death (34.3–55.5%) in patients with pemphigus. Skin was usually the origin of infections. The study aimed to explore features and associated factors of bacterial skin infections (BSIs) in inpatients with pemphigus. Methods One hundred and seventy-seven inpatients with pemphigus hospitalizing from November 2014 to April 2019 were continuously recruited through Peking University First Hospital’s inpatient records inpatients with pemphigus hospitalizing from November 2014 to April 2019 were continuously recruited through Peking University First Hospital’s inpatient records. Then, we retrieved the clinical and laboratory data to explore the characteristics and associated factors of BSIs. Results Of patients enrolled, pemphigus vulgaris (PV, n = 142) and pemphigus foliaceus (PF, n = 9) were most common, followed by pemphigus erythematosus (PE, n = 25) and pemphigus vegetans (Pveg, n = 1). Eighty-seven of 177 (49.2%) inpatients developed BSIs, and they had a longer length of stay compared with inpatients without BSIs (median: 18.9 vs. 14.1 days, p = 0.008). Staphylococcus aureus was the most common bacteria (71.3%, 62/87) and highly resistant to penicillin (91.9%, 57/62). Higher levels of anti-Dsg1 autoantibodies (> 124.2 U/mL) (p < 0.001, odds ratio [OR] = 3.564, 95% confidence interval [CI]: 1.784–7.123) and anti-Dsg3 autoantibodies (> 169.5 U/mL) (p = 0.03, OR = 2.074, 95% CI: 1.084–3.969) were underlying risk factors of BSIs when analyzed by binary regression analysis. As for Gram’s stain of bacteria, females had a lower rate of Gram-positive infections (p = 0.03). Patients using oral antibiotics (p = 0.05) had a higher rate of Gram-negative infections. Inpatients who were hospitalized in other hospitals within 2 weeks before the current admission had a higher rate of Gram-negative and co-infections (p = 0.03). Conclusions Inpatients with pemphigus had a high incidence of BSIs. Some factors were associated with the susceptibility of BSIs and bacterial species. |
| first_indexed | 2024-12-11T17:34:46Z |
| format | Article |
| id | doaj.art-47f81ec259ed43128a7fb3aacccad55b |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-12-11T17:34:46Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-47f81ec259ed43128a7fb3aacccad55b2022-12-22T00:56:42ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112020-10-011911910.1186/s12941-020-00388-6Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective studyFurong Li0Yejun Wu1Wenjie Bian2Lei Huang3Xuejun Zhu4Xixue Chen5Mingyue Wang6Department of Dermatology, Peking University First HospitalDepartment of Eight-year Clinical Medical Education, Peking University People’s HospitalDepartment of Eight-year Clinical Medical Education, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University First HospitalDepartment of Dermatology, Peking University First HospitalDepartment of Dermatology, Peking University First HospitalDepartment of Dermatology, Peking University First HospitalAbstract Background Infections were the primary cause of death (34.3–55.5%) in patients with pemphigus. Skin was usually the origin of infections. The study aimed to explore features and associated factors of bacterial skin infections (BSIs) in inpatients with pemphigus. Methods One hundred and seventy-seven inpatients with pemphigus hospitalizing from November 2014 to April 2019 were continuously recruited through Peking University First Hospital’s inpatient records inpatients with pemphigus hospitalizing from November 2014 to April 2019 were continuously recruited through Peking University First Hospital’s inpatient records. Then, we retrieved the clinical and laboratory data to explore the characteristics and associated factors of BSIs. Results Of patients enrolled, pemphigus vulgaris (PV, n = 142) and pemphigus foliaceus (PF, n = 9) were most common, followed by pemphigus erythematosus (PE, n = 25) and pemphigus vegetans (Pveg, n = 1). Eighty-seven of 177 (49.2%) inpatients developed BSIs, and they had a longer length of stay compared with inpatients without BSIs (median: 18.9 vs. 14.1 days, p = 0.008). Staphylococcus aureus was the most common bacteria (71.3%, 62/87) and highly resistant to penicillin (91.9%, 57/62). Higher levels of anti-Dsg1 autoantibodies (> 124.2 U/mL) (p < 0.001, odds ratio [OR] = 3.564, 95% confidence interval [CI]: 1.784–7.123) and anti-Dsg3 autoantibodies (> 169.5 U/mL) (p = 0.03, OR = 2.074, 95% CI: 1.084–3.969) were underlying risk factors of BSIs when analyzed by binary regression analysis. As for Gram’s stain of bacteria, females had a lower rate of Gram-positive infections (p = 0.03). Patients using oral antibiotics (p = 0.05) had a higher rate of Gram-negative infections. Inpatients who were hospitalized in other hospitals within 2 weeks before the current admission had a higher rate of Gram-negative and co-infections (p = 0.03). Conclusions Inpatients with pemphigus had a high incidence of BSIs. Some factors were associated with the susceptibility of BSIs and bacterial species.http://link.springer.com/article/10.1186/s12941-020-00388-6Bacterial skin infectionsPemphigusAntibioticsGram’s stainStaphylococcus aureus |
| spellingShingle | Furong Li Yejun Wu Wenjie Bian Lei Huang Xuejun Zhu Xixue Chen Mingyue Wang Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study Annals of Clinical Microbiology and Antimicrobials Bacterial skin infections Pemphigus Antibiotics Gram’s stain Staphylococcus aureus |
| title | Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study |
| title_full | Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study |
| title_fullStr | Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study |
| title_full_unstemmed | Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study |
| title_short | Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study |
| title_sort | features and associated factors of bacterial skin infections in hospitalized patients with pemphigus a single center retrospective study |
| topic | Bacterial skin infections Pemphigus Antibiotics Gram’s stain Staphylococcus aureus |
| url | http://link.springer.com/article/10.1186/s12941-020-00388-6 |
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