In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study
In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional...
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00639/full |
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| author | Wenxu Qi Peinan Zhao Wei Wang Zhexian Sun Zhexian Sun Xiao Ma Xiao Ma Hui Wang Hui Wang Wenjie Wu Wenjie Wu Zichao Wen Zulfia Kisrieva-Ware Pamela K. Woodard Qing Wang Robert C. McKinstry Yong Wang Yong Wang Yong Wang Yong Wang |
| author_facet | Wenxu Qi Peinan Zhao Wei Wang Zhexian Sun Zhexian Sun Xiao Ma Xiao Ma Hui Wang Hui Wang Wenjie Wu Wenjie Wu Zichao Wen Zulfia Kisrieva-Ware Pamela K. Woodard Qing Wang Robert C. McKinstry Yong Wang Yong Wang Yong Wang Yong Wang |
| author_sort | Wenxu Qi |
| collection | DOAJ |
| description | In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state (3D-CISS) sequence to examine the FM at the cervical internal os zone during pregnancy; 18 pregnant women with one to three longitudinal MRI scans were included in this study. In 14 women, the FM appeared normal and completely intact. In four women, we noted several FM abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the FM ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that improves examination of the FMs. |
| first_indexed | 2024-12-11T02:07:28Z |
| format | Article |
| id | doaj.art-47f98101a1fc488e9ce88211e21ca400 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T02:07:28Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-47f98101a1fc488e9ce88211e21ca4002022-12-22T01:24:21ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-06-011110.3389/fphys.2020.00639548303In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary StudyWenxu Qi0Peinan Zhao1Wei Wang2Zhexian Sun3Zhexian Sun4Xiao Ma5Xiao Ma6Hui Wang7Hui Wang8Wenjie Wu9Wenjie Wu10Zichao Wen11Zulfia Kisrieva-Ware12Pamela K. Woodard13Qing Wang14Robert C. McKinstry15Yong Wang16Yong Wang17Yong Wang18Yong Wang19Department of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesMallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Physics, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesMallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesMallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesMallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesMallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Physics, Washington University in St. Louis, St. Louis, MO, United StatesIn approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state (3D-CISS) sequence to examine the FM at the cervical internal os zone during pregnancy; 18 pregnant women with one to three longitudinal MRI scans were included in this study. In 14 women, the FM appeared normal and completely intact. In four women, we noted several FM abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the FM ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that improves examination of the FMs.https://www.frontiersin.org/article/10.3389/fphys.2020.00639/fullamnionchorionfetal membranepreterm birthpremature rupture of membranespreterm premature rupture of membranes |
| spellingShingle | Wenxu Qi Peinan Zhao Wei Wang Zhexian Sun Zhexian Sun Xiao Ma Xiao Ma Hui Wang Hui Wang Wenjie Wu Wenjie Wu Zichao Wen Zulfia Kisrieva-Ware Pamela K. Woodard Qing Wang Robert C. McKinstry Yong Wang Yong Wang Yong Wang Yong Wang In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study Frontiers in Physiology amnion chorion fetal membrane preterm birth premature rupture of membranes preterm premature rupture of membranes |
| title | In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study |
| title_full | In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study |
| title_fullStr | In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study |
| title_full_unstemmed | In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study |
| title_short | In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study |
| title_sort | in vivo assessment of supra cervical fetal membrane by mri 3d ciss a preliminary study |
| topic | amnion chorion fetal membrane preterm birth premature rupture of membranes preterm premature rupture of membranes |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00639/full |
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