mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32487-7 |
| _version_ | 1798042655594119168 |
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| author | Stéphanie Kaeser-Pebernard Christine Vionnet Muriel Mari Devanarayanan Siva Sankar Zehan Hu Carole Roubaty Esther Martínez-Martínez Huiyuan Zhao Miguel Spuch-Calvar Alke Petri-Fink Gregor Rainer Florian Steinberg Fulvio Reggiori Jörn Dengjel |
| author_facet | Stéphanie Kaeser-Pebernard Christine Vionnet Muriel Mari Devanarayanan Siva Sankar Zehan Hu Carole Roubaty Esther Martínez-Martínez Huiyuan Zhao Miguel Spuch-Calvar Alke Petri-Fink Gregor Rainer Florian Steinberg Fulvio Reggiori Jörn Dengjel |
| author_sort | Stéphanie Kaeser-Pebernard |
| collection | DOAJ |
| description | mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1. |
| first_indexed | 2024-04-11T22:38:30Z |
| format | Article |
| id | doaj.art-47fafe05ef1d4bfc9dcefd8a49f743f9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T22:38:30Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-47fafe05ef1d4bfc9dcefd8a49f743f92022-12-22T03:59:06ZengNature PortfolioNature Communications2041-17232022-08-0113112110.1038/s41467-022-32487-7mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1Stéphanie Kaeser-Pebernard0Christine Vionnet1Muriel Mari2Devanarayanan Siva Sankar3Zehan Hu4Carole Roubaty5Esther Martínez-Martínez6Huiyuan Zhao7Miguel Spuch-Calvar8Alke Petri-Fink9Gregor Rainer10Florian Steinberg11Fulvio Reggiori12Jörn Dengjel13Department of Biology, University of FribourgDepartment of Biology, University of FribourgDepartment of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center GroningenDepartment of Biology, University of FribourgDepartment of Biology, University of FribourgDepartment of Biology, University of FribourgDepartment of Biology, University of FribourgSection of Medicine, University of FribourgAdolf Merkle Institute, University of FribourgAdolf Merkle Institute, University of FribourgSection of Medicine, University of FribourgCenter for Biological Systems Analysis, University of FreiburgDepartment of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center GroningenDepartment of Biology, University of FribourgmTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.https://doi.org/10.1038/s41467-022-32487-7 |
| spellingShingle | Stéphanie Kaeser-Pebernard Christine Vionnet Muriel Mari Devanarayanan Siva Sankar Zehan Hu Carole Roubaty Esther Martínez-Martínez Huiyuan Zhao Miguel Spuch-Calvar Alke Petri-Fink Gregor Rainer Florian Steinberg Fulvio Reggiori Jörn Dengjel mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 Nature Communications |
| title | mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 |
| title_full | mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 |
| title_fullStr | mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 |
| title_full_unstemmed | mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 |
| title_short | mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 |
| title_sort | mtorc1 controls golgi architecture and vesicle secretion by phosphorylation of scyl1 |
| url | https://doi.org/10.1038/s41467-022-32487-7 |
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