Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study
ObjectiveRetinal vein occlusion (RVO) is the second most common retinal vascular disorder after diabetic retinopathy, which is the main cause of vision loss. Retinal vein occlusion might lead to macular edema, causing severe vision loss. Previous neuroimaging studies of patients with RVO demonstrate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.961972/full |
| _version_ | 1797995234280341504 |
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| author | Yu Mei Xiao Fan Gan Hui Liu Yu Lin Zhong |
| author_facet | Yu Mei Xiao Fan Gan Hui Liu Yu Lin Zhong |
| author_sort | Yu Mei Xiao |
| collection | DOAJ |
| description | ObjectiveRetinal vein occlusion (RVO) is the second most common retinal vascular disorder after diabetic retinopathy, which is the main cause of vision loss. Retinal vein occlusion might lead to macular edema, causing severe vision loss. Previous neuroimaging studies of patients with RVO demonstrated that RVO was accompanied by cerebral changes, and was related to stroke. The purpose of the study is to investigate synchronous neural activity changes in patients with RVO.MethodsA total of 50 patients with RVO and 48 healthy subjects with matched sex, age, and education were enrolled in the study. The ReHo method was applied to investigate synchronous neural activity changes in patients with RVO.ResultsCompared with HC, patients with RVO showed increased ReHo values in the bilateral cerebellum_4_5. On the contrary, patients with RVO had decreased ReHo values in the bilateral middle occipital gyrus, right cerebelum_crus1, and right inferior temporal gyrus.ConclusionOur study demonstrated that patients with RVO were associated with abnormal synchronous neural activities in the cerebellum, middle occipital gyrus, and inferior temporal gyrus. These findings shed new insight into neural mechanisms of vision loss in patients with RVO. |
| first_indexed | 2024-04-11T09:58:14Z |
| format | Article |
| id | doaj.art-47fb536656c446f58600bd9f19908adc |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-11T09:58:14Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-47fb536656c446f58600bd9f19908adc2022-12-22T04:30:30ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-09-011610.3389/fnhum.2022.961972961972Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI studyYu Mei Xiao0Fan Gan1Hui Liu2Yu Lin Zhong3Department of Operation, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaObjectiveRetinal vein occlusion (RVO) is the second most common retinal vascular disorder after diabetic retinopathy, which is the main cause of vision loss. Retinal vein occlusion might lead to macular edema, causing severe vision loss. Previous neuroimaging studies of patients with RVO demonstrated that RVO was accompanied by cerebral changes, and was related to stroke. The purpose of the study is to investigate synchronous neural activity changes in patients with RVO.MethodsA total of 50 patients with RVO and 48 healthy subjects with matched sex, age, and education were enrolled in the study. The ReHo method was applied to investigate synchronous neural activity changes in patients with RVO.ResultsCompared with HC, patients with RVO showed increased ReHo values in the bilateral cerebellum_4_5. On the contrary, patients with RVO had decreased ReHo values in the bilateral middle occipital gyrus, right cerebelum_crus1, and right inferior temporal gyrus.ConclusionOur study demonstrated that patients with RVO were associated with abnormal synchronous neural activities in the cerebellum, middle occipital gyrus, and inferior temporal gyrus. These findings shed new insight into neural mechanisms of vision loss in patients with RVO.https://www.frontiersin.org/articles/10.3389/fnhum.2022.961972/fullretinal vein occlusionregional homogeneityresting-state fMRIbrain activityfMRI |
| spellingShingle | Yu Mei Xiao Fan Gan Hui Liu Yu Lin Zhong Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study Frontiers in Human Neuroscience retinal vein occlusion regional homogeneity resting-state fMRI brain activity fMRI |
| title | Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study |
| title_full | Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study |
| title_fullStr | Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study |
| title_full_unstemmed | Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study |
| title_short | Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study |
| title_sort | altered synchronous neural activities in retinal vein occlusion patients a resting state fmri study |
| topic | retinal vein occlusion regional homogeneity resting-state fMRI brain activity fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.961972/full |
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