Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing
Background Macrophages play a major role in wound healing and prevent infection from the outside. Polarization conversion of macrophages regulates aspects of inflammation, and two macrophages, M1 (classically activated) and M2 (alternatively activated), exist at both ends of broad-spectru...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2023-07-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770114 |
| _version_ | 1827799484719955968 |
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| author | Mun Ho Oh JaeHyuk Jang Jong Hun Lee |
| author_facet | Mun Ho Oh JaeHyuk Jang Jong Hun Lee |
| author_sort | Mun Ho Oh |
| collection | DOAJ |
| description |
Background Macrophages play a major role in wound healing and prevent infection from the outside. Polarization conversion of macrophages regulates aspects of inflammation, and two macrophages, M1 (classically activated) and M2 (alternatively activated), exist at both ends of broad-spectrum macrophage polarization. Thus, we aimed to investigate whether macrophage polarization can be artificially regulated. To this end, MgSO4 and small-interfering RNA (siRNA) targeting magnesium transport 1 (MAGT1) were used to investigate the effects of intracellular magnesium (Mg2+) concentrations on the differentiation of macrophages in vitro. |
| first_indexed | 2024-03-11T19:53:09Z |
| format | Article |
| id | doaj.art-47fc1571b7634138af36fdfb2bf9096a |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-03-11T19:53:09Z |
| publishDate | 2023-07-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-47fc1571b7634138af36fdfb2bf9096a2023-10-04T23:26:16ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712023-07-01500443244210.1055/s-0043-1770114Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound HealingMun Ho Oh0https://orcid.org/0009-0005-8659-7083JaeHyuk Jang1https://orcid.org/0000-0003-1005-5905Jong Hun Lee2https://orcid.org/0000-0001-6417-6986Eulji Medi-Bio Research Institute, Eulji University, Seoul, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, School of Medicine, Eulji University, Seoul, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, School of Medicine, Eulji University, Seoul, Republic of Korea Background Macrophages play a major role in wound healing and prevent infection from the outside. Polarization conversion of macrophages regulates aspects of inflammation, and two macrophages, M1 (classically activated) and M2 (alternatively activated), exist at both ends of broad-spectrum macrophage polarization. Thus, we aimed to investigate whether macrophage polarization can be artificially regulated. To this end, MgSO4 and small-interfering RNA (siRNA) targeting magnesium transport 1 (MAGT1) were used to investigate the effects of intracellular magnesium (Mg2+) concentrations on the differentiation of macrophages in vitro.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770114wound healingmagnesiummacrophagedifferentiationpolarization |
| spellingShingle | Mun Ho Oh JaeHyuk Jang Jong Hun Lee Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing Archives of Plastic Surgery wound healing magnesium macrophage differentiation polarization |
| title | Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing |
| title_full | Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing |
| title_fullStr | Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing |
| title_full_unstemmed | Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing |
| title_short | Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing |
| title_sort | polarization of thp 1 derived macrophage by magnesium and magt1 inhibition in wound healing |
| topic | wound healing magnesium macrophage differentiation polarization |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770114 |
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