Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.
Pediatric intracranial ependymoma has seen a recent exponential expansion of biological findings, rapidly dividing the diagnosis into several subgroups, each with specific molecular and clinical characteristics. While such subdivision may complicate clinical conclusions from historical trials, this...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558623000209 |
| _version_ | 1797851294815223808 |
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| author | Eugene I. Hwang Derek Hanson Mariella G. Filbin Stephen C. Mack |
| author_facet | Eugene I. Hwang Derek Hanson Mariella G. Filbin Stephen C. Mack |
| author_sort | Eugene I. Hwang |
| collection | DOAJ |
| description | Pediatric intracranial ependymoma has seen a recent exponential expansion of biological findings, rapidly dividing the diagnosis into several subgroups, each with specific molecular and clinical characteristics. While such subdivision may complicate clinical conclusions from historical trials, this knowledge also provides an opportunity for interrogating the major clinical and biological questions preventing near-term translation into effective therapy for children with ependymoma. In this article, we briefly review some of the most critical clinical questions facing both patient management and the construct of future trials in childhood ependymoma, as well as explore some of the current barriers to efficient translation of preclinical discovery to the clinic. |
| first_indexed | 2024-04-09T19:15:35Z |
| format | Article |
| id | doaj.art-47fd6b923a984b0892d3df6321ff8cfa |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-04-09T19:15:35Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-47fd6b923a984b0892d3df6321ff8cfa2023-04-06T06:10:32ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862023-05-0139100895Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.Eugene I. Hwang0Derek Hanson1Mariella G. Filbin2Stephen C. Mack3Children's National Hospital; Corresponding author.Hackensack Meridian HealthDana-Farber/Boston Children's Cancer and Blood Disorders CenterSt. Jude Children's Research HospitalPediatric intracranial ependymoma has seen a recent exponential expansion of biological findings, rapidly dividing the diagnosis into several subgroups, each with specific molecular and clinical characteristics. While such subdivision may complicate clinical conclusions from historical trials, this knowledge also provides an opportunity for interrogating the major clinical and biological questions preventing near-term translation into effective therapy for children with ependymoma. In this article, we briefly review some of the most critical clinical questions facing both patient management and the construct of future trials in childhood ependymoma, as well as explore some of the current barriers to efficient translation of preclinical discovery to the clinic.http://www.sciencedirect.com/science/article/pii/S1476558623000209Pediatric brain cancerChildhood ependymomaTranslational barriersAnaplasiaChemotherapyRadiation |
| spellingShingle | Eugene I. Hwang Derek Hanson Mariella G. Filbin Stephen C. Mack Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. Neoplasia: An International Journal for Oncology Research Pediatric brain cancer Childhood ependymoma Translational barriers Anaplasia Chemotherapy Radiation |
| title | Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. |
| title_full | Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. |
| title_fullStr | Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. |
| title_full_unstemmed | Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. |
| title_short | Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. |
| title_sort | why haven t we solved intracranial pediatric ependymoma current questions and barriers to treatment advances |
| topic | Pediatric brain cancer Childhood ependymoma Translational barriers Anaplasia Chemotherapy Radiation |
| url | http://www.sciencedirect.com/science/article/pii/S1476558623000209 |
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