Stereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculation
Abstract Background Stereotactic irradiation is one of the treatment modalities for intraocular uveal melanoma. The study’s purpose was to describe the background of stereotactic one-day session radiosurgery, how the comparison in the difference between the tumor volume measured values from the magn...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02558-w |
| _version_ | 1828293938820153344 |
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| author | Alena Furdova Robert Furda Miron Sramka Martin Chorvath Jan Rybar Pavol Vesely Jela Valaskova Vladimir Siska |
| author_facet | Alena Furdova Robert Furda Miron Sramka Martin Chorvath Jan Rybar Pavol Vesely Jela Valaskova Vladimir Siska |
| author_sort | Alena Furdova |
| collection | DOAJ |
| description | Abstract Background Stereotactic irradiation is one of the treatment modalities for intraocular uveal melanoma. The study’s purpose was to describe the background of stereotactic one-day session radiosurgery, how the comparison in the difference between the tumor volume measured values from the magnetic resonance imaging (MRI) method and the ultrasound method was related to it, and which method was more precise to be used for tumor regression after irradiation. Methods The group of 147 patients with choroidal melanoma was treated by stereotactic irradiation on the linear accelerator with a single dose of 35.0 Gy. During the standard treatment process the uveal melanoma volumes, needed for dose calculation, were obtained using MRI from the individual stereotactic planning scheme and by ultrasound from the ultrasound device. All volumes were statistically compared using the paired t-test, and for the visualization purpose, the Bland-Altman plot was used. Results In the group of patients, it was 70 (47.6%) males and 77 (52.4%) females. The tumor volume median was from MRI equal to 0.44 cm3 and from ultrasound equal to 0.53 cm3. The difference between the ultrasound and the MRI volume measured values was statistically significant. However, the Bland-Altman plot clearly documents that the two methods are in agreement and can be used interchangeably. In most of the cases, the measured values of the ultrasound-calculated volume achieved slightly higher measured values. Conclusions The calculation of the intraocular uveal tumor volume is a crucial part of the stereotactic irradiation treatment. The ultrasound volume measured values were in most of the cases higher than the measured values from the MRI. Although the methods are comparable and can be used interchangeably, we are recommending using the more precise MRI method not only during the treatment but also on later regular medical checks of tumor regression or progression. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T11:28:30Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-47fed8dbb56f4c17a173acb70948e7b92022-12-22T02:48:37ZengBMCBMC Ophthalmology1471-24152022-08-0122111010.1186/s12886-022-02558-wStereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculationAlena Furdova0Robert Furda1Miron Sramka2Martin Chorvath3Jan Rybar4Pavol Vesely5Jela Valaskova6Vladimir Siska7Department of Ophthalmology, Faculty of Medicine, Hospital Ruzinov, Comenius University BratislavaDepartment of Information Systems, Faculty of Management, Comenius University BratislavaDepartment of Stereotactic Radiosurgery, St. Elisabeth Cancer Institute and St. Elisabeth University College of Health and Social WorkDepartment of Stereotactic Radiosurgery, St. Elisabeth Cancer Institute and St. Elisabeth University College of Health and Social WorkInstitute of Automation, Measurement and Applied Informatics, Faculty of Mechanical Engineering, Slovak University of TechnologyDepartment of Ophthalmology, Faculty of Medicine, Hospital Ruzinov, Comenius University BratislavaDepartment of Ophthalmology, Faculty of Medicine, Hospital Ruzinov, Comenius University BratislavaDepartment of Ophthalmology, Faculty of Medicine, Hospital Ruzinov, Comenius University BratislavaAbstract Background Stereotactic irradiation is one of the treatment modalities for intraocular uveal melanoma. The study’s purpose was to describe the background of stereotactic one-day session radiosurgery, how the comparison in the difference between the tumor volume measured values from the magnetic resonance imaging (MRI) method and the ultrasound method was related to it, and which method was more precise to be used for tumor regression after irradiation. Methods The group of 147 patients with choroidal melanoma was treated by stereotactic irradiation on the linear accelerator with a single dose of 35.0 Gy. During the standard treatment process the uveal melanoma volumes, needed for dose calculation, were obtained using MRI from the individual stereotactic planning scheme and by ultrasound from the ultrasound device. All volumes were statistically compared using the paired t-test, and for the visualization purpose, the Bland-Altman plot was used. Results In the group of patients, it was 70 (47.6%) males and 77 (52.4%) females. The tumor volume median was from MRI equal to 0.44 cm3 and from ultrasound equal to 0.53 cm3. The difference between the ultrasound and the MRI volume measured values was statistically significant. However, the Bland-Altman plot clearly documents that the two methods are in agreement and can be used interchangeably. In most of the cases, the measured values of the ultrasound-calculated volume achieved slightly higher measured values. Conclusions The calculation of the intraocular uveal tumor volume is a crucial part of the stereotactic irradiation treatment. The ultrasound volume measured values were in most of the cases higher than the measured values from the MRI. Although the methods are comparable and can be used interchangeably, we are recommending using the more precise MRI method not only during the treatment but also on later regular medical checks of tumor regression or progression.https://doi.org/10.1186/s12886-022-02558-wIntraocular tumorsUveal melanomaUltrasoundMagnetic resonance imagingStereotactic irradiation |
| spellingShingle | Alena Furdova Robert Furda Miron Sramka Martin Chorvath Jan Rybar Pavol Vesely Jela Valaskova Vladimir Siska Stereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculation BMC Ophthalmology Intraocular tumors Uveal melanoma Ultrasound Magnetic resonance imaging Stereotactic irradiation |
| title | Stereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculation |
| title_full | Stereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculation |
| title_fullStr | Stereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculation |
| title_full_unstemmed | Stereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculation |
| title_short | Stereotactic irradiation on linear accelerator - ultrasound versus MRI in choroidal melanoma volume calculation |
| title_sort | stereotactic irradiation on linear accelerator ultrasound versus mri in choroidal melanoma volume calculation |
| topic | Intraocular tumors Uveal melanoma Ultrasound Magnetic resonance imaging Stereotactic irradiation |
| url | https://doi.org/10.1186/s12886-022-02558-w |
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