The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis
Of the ~60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/10/2/80 |
| _version_ | 1811264509132668928 |
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| author | Lisa Mirabello Megan A. Clarke Chase W. Nelson Michael Dean Nicolas Wentzensen Meredith Yeager Michael Cullen Joseph F. Boland NCI HPV Workshop Mark Schiffman Robert D. Burk |
| author_facet | Lisa Mirabello Megan A. Clarke Chase W. Nelson Michael Dean Nicolas Wentzensen Meredith Yeager Michael Cullen Joseph F. Boland NCI HPV Workshop Mark Schiffman Robert D. Burk |
| author_sort | Lisa Mirabello |
| collection | DOAJ |
| description | Of the ~60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16 can differ in their carcinogenicity by 10-fold or more in epidemiologic studies. Strong genotype-phenotype associations embedded in the small 8-kb HPV16 genome motivate molecular studies to understand the underlying molecular mechanisms. Understanding the mechanisms of HPV genomic findings is complicated by the linkage of HPV genome variants. A panel of experts in various disciplines gathered on 21 November 2016 to discuss the interdisciplinary science of HPV oncogenesis. Here, we summarize the discussion of the complexity of the viral–host interaction and highlight important next steps for selected applied basic laboratory studies guided by epidemiological genomic findings. |
| first_indexed | 2024-04-12T20:05:33Z |
| format | Article |
| id | doaj.art-47ffa859d2e04d3dbe2f599d2c6681c0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-12T20:05:33Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-47ffa859d2e04d3dbe2f599d2c6681c02022-12-22T03:18:24ZengMDPI AGViruses1999-49152018-02-011028010.3390/v10020080v10020080The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated CarcinogenesisLisa Mirabello0Megan A. Clarke1Chase W. Nelson2Michael Dean3Nicolas Wentzensen4Meredith Yeager5Michael Cullen6Joseph F. Boland7NCI HPV Workshop8Mark Schiffman9Robert D. Burk10Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USANCI HPV Workshop, DCEG, Rockville, MD 20850, USADivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USADepartments of Pediatrics, Microbiology and Immunology, Epidemiology and Population Health, and Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY 10461, USAOf the ~60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16 can differ in their carcinogenicity by 10-fold or more in epidemiologic studies. Strong genotype-phenotype associations embedded in the small 8-kb HPV16 genome motivate molecular studies to understand the underlying molecular mechanisms. Understanding the mechanisms of HPV genomic findings is complicated by the linkage of HPV genome variants. A panel of experts in various disciplines gathered on 21 November 2016 to discuss the interdisciplinary science of HPV oncogenesis. Here, we summarize the discussion of the complexity of the viral–host interaction and highlight important next steps for selected applied basic laboratory studies guided by epidemiological genomic findings.http://www.mdpi.com/1999-4915/10/2/80HPV carcinogenesisHPV epidemiologyHPV genomicsviral–host interactionsHPV16 |
| spellingShingle | Lisa Mirabello Megan A. Clarke Chase W. Nelson Michael Dean Nicolas Wentzensen Meredith Yeager Michael Cullen Joseph F. Boland NCI HPV Workshop Mark Schiffman Robert D. Burk The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis Viruses HPV carcinogenesis HPV epidemiology HPV genomics viral–host interactions HPV16 |
| title | The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis |
| title_full | The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis |
| title_fullStr | The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis |
| title_full_unstemmed | The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis |
| title_short | The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis |
| title_sort | intersection of hpv epidemiology genomics and mechanistic studies of hpv mediated carcinogenesis |
| topic | HPV carcinogenesis HPV epidemiology HPV genomics viral–host interactions HPV16 |
| url | http://www.mdpi.com/1999-4915/10/2/80 |
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