CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

Abstract Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub. Primary cilium-elicited signalling, and how it affects migration, remain however ill char...

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Bibliographic Details
Main Authors: Melody Atkins, Maud Wurmser, Michèle Darmon, Fiona Roche, Xavier Nicol, Christine Métin
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43645-w

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