Injection of botulinum toxin type a to reduce saliva in patients with neurological diseases
Objective: To demonstrate the effect of local injection of Botox® inpatients with neurological diseases, following our protocol for thetreatment of sialorrhea. Study design: clinical prospective study.Methods: Twenty-one patients with neurological diseases seen atthe Otorhinolaryngology of the Assoc...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2005-09-01
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.einstein.br/revista/biblioteca/artigos/vol3/num_3/Vol3_N3_P174.pdf |
| _version_ | 1818355599650324480 |
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| author | Dayse Manrique |
| author_facet | Dayse Manrique |
| author_sort | Dayse Manrique |
| collection | DOAJ |
| description | Objective: To demonstrate the effect of local injection of Botox® inpatients with neurological diseases, following our protocol for thetreatment of sialorrhea. Study design: clinical prospective study.Methods: Twenty-one patients with neurological diseases seen atthe Otorhinolaryngology of the Associação de Assistência à CriançaDeficiente. They were all submitted to local injection of Botox® insalivary glands and followed up for one year. The protocol consistsof a clinical questionnaire about inability to swallow saliva and itsrepercussions in general health and quality of life. Patients must nothave periodontal disease or intolerance to adverse effects ofanticholinergic agents and must not have used Botox® at least inthe last six months. The injection was ultrasonographically guidedand the dose was 30 U in one site of the submandibular glands, and20 U in two sites in each parotid gland. Results: Twenty-one patientswith sialorrhea resulting from several neurological diseases (chronicencephalopathy, Parkinson’s disease, amyotrophic lateral sclerosis,neuromuscular diseases, cerebral tumor, trauma), aged 2 to 66 yearsold, were submitted to Botox® injection in their salivary glands. Weobserved a markedly improvement of sialorrhea in all but one patient.Seventeen patients had no complaints of sialorrhea or salivaaspiration for approximately four months with good repercussion intheir quality of life. No patient presented local or systemic effectswith local injection of Botox®. Conclusion: the injection of Botox® asindicated in the present study was able to reduce sialorrhea resultingfrom several neurological conditions. |
| first_indexed | 2024-12-13T19:43:53Z |
| format | Article |
| id | doaj.art-4800b912ae2245e08ee3c353ce1dbf7b |
| institution | Directory Open Access Journal |
| issn | 1679-4508 |
| language | English |
| last_indexed | 2024-12-13T19:43:53Z |
| publishDate | 2005-09-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-4800b912ae2245e08ee3c353ce1dbf7b2022-12-21T23:33:36ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082005-09-0133174178Injection of botulinum toxin type a to reduce saliva in patients with neurological diseasesDayse ManriqueObjective: To demonstrate the effect of local injection of Botox® inpatients with neurological diseases, following our protocol for thetreatment of sialorrhea. Study design: clinical prospective study.Methods: Twenty-one patients with neurological diseases seen atthe Otorhinolaryngology of the Associação de Assistência à CriançaDeficiente. They were all submitted to local injection of Botox® insalivary glands and followed up for one year. The protocol consistsof a clinical questionnaire about inability to swallow saliva and itsrepercussions in general health and quality of life. Patients must nothave periodontal disease or intolerance to adverse effects ofanticholinergic agents and must not have used Botox® at least inthe last six months. The injection was ultrasonographically guidedand the dose was 30 U in one site of the submandibular glands, and20 U in two sites in each parotid gland. Results: Twenty-one patientswith sialorrhea resulting from several neurological diseases (chronicencephalopathy, Parkinson’s disease, amyotrophic lateral sclerosis,neuromuscular diseases, cerebral tumor, trauma), aged 2 to 66 yearsold, were submitted to Botox® injection in their salivary glands. Weobserved a markedly improvement of sialorrhea in all but one patient.Seventeen patients had no complaints of sialorrhea or salivaaspiration for approximately four months with good repercussion intheir quality of life. No patient presented local or systemic effectswith local injection of Botox®. Conclusion: the injection of Botox® asindicated in the present study was able to reduce sialorrhea resultingfrom several neurological conditions.http://www.einstein.br/revista/biblioteca/artigos/vol3/num_3/Vol3_N3_P174.pdfSalivary glandsBotulinum toxin type A /therapeutic useSialorrhea/drug therapyDysphagiaNervous system diseases |
| spellingShingle | Dayse Manrique Injection of botulinum toxin type a to reduce saliva in patients with neurological diseases Einstein (São Paulo) Salivary glands Botulinum toxin type A /therapeutic use Sialorrhea/drug therapy Dysphagia Nervous system diseases |
| title | Injection of botulinum toxin type a to reduce saliva in patients with neurological diseases |
| title_full | Injection of botulinum toxin type a to reduce saliva in patients with neurological diseases |
| title_fullStr | Injection of botulinum toxin type a to reduce saliva in patients with neurological diseases |
| title_full_unstemmed | Injection of botulinum toxin type a to reduce saliva in patients with neurological diseases |
| title_short | Injection of botulinum toxin type a to reduce saliva in patients with neurological diseases |
| title_sort | injection of botulinum toxin type a to reduce saliva in patients with neurological diseases |
| topic | Salivary glands Botulinum toxin type A /therapeutic use Sialorrhea/drug therapy Dysphagia Nervous system diseases |
| url | http://www.einstein.br/revista/biblioteca/artigos/vol3/num_3/Vol3_N3_P174.pdf |
| work_keys_str_mv | AT daysemanrique injectionofbotulinumtoxintypeatoreducesalivainpatientswithneurologicaldiseases |