The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em>
Phycocyanin is an excellent antioxidant with anti-inflammatory effects on which recent studies are growing; however, its specific target remains unclear. Linear tetrapyrrole compounds such as bilirubin have been shown to lead to the induction of heme oxygenase 1 expression <i>in vivo</i>...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/11/696 |
| _version_ | 1797467508218789888 |
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| author | Run-Ze Liu Wen-Jun Li Juan-Juan Zhang Zheng-Yi Liu Ya Li Chao Liu Song Qin |
| author_facet | Run-Ze Liu Wen-Jun Li Juan-Juan Zhang Zheng-Yi Liu Ya Li Chao Liu Song Qin |
| author_sort | Run-Ze Liu |
| collection | DOAJ |
| description | Phycocyanin is an excellent antioxidant with anti-inflammatory effects on which recent studies are growing; however, its specific target remains unclear. Linear tetrapyrrole compounds such as bilirubin have been shown to lead to the induction of heme oxygenase 1 expression <i>in vivo</i>, thus achieving antioxidant and anti-inflammatory effects. Phycocyanin is bound internally with linear tetrapyrrole phycocyanobilin in a similar structure to bilirubin. We speculate that there is probably a way of inducing the expression of heme oxygenase 1, with which tissue oxidative stress and inflammation can be inhibited, thus inhibiting pulmonary fibrosis caused by oxidative damage and inflammation of lung. By optimizing the enzymatic hydrolysis process, phycocyanobilin-bound phycocyanin peptide were obtained, and its <i>in vitro</i> antioxidant, anti-inflammatory, and anti-pulmonary fibrosis activities were investigated. The results show that the phycocyanobilin peptide was able to alleviate oxidative and inflammatory damage in cells through the Keap1-Nrf2-HO-1 pathway, which in turn relieved pulmonary fibrosis symptoms. |
| first_indexed | 2024-03-09T18:53:39Z |
| format | Article |
| id | doaj.art-480126817e0647869825a2db42a72d29 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T18:53:39Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-480126817e0647869825a2db42a72d292023-11-24T05:34:35ZengMDPI AGMarine Drugs1660-33972022-11-01201169610.3390/md20110696The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em>Run-Ze Liu0Wen-Jun Li1Juan-Juan Zhang2Zheng-Yi Liu3Ya Li4Chao Liu5Song Qin6Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, ChinaYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, ChinaYantai Jiahui Biotech Co., Ltd., Yantai 264003, ChinaYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, ChinaYantai Jiahui Biotech Co., Ltd., Yantai 264003, ChinaYantai Jiahui Biotech Co., Ltd., Yantai 264003, ChinaYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, ChinaPhycocyanin is an excellent antioxidant with anti-inflammatory effects on which recent studies are growing; however, its specific target remains unclear. Linear tetrapyrrole compounds such as bilirubin have been shown to lead to the induction of heme oxygenase 1 expression <i>in vivo</i>, thus achieving antioxidant and anti-inflammatory effects. Phycocyanin is bound internally with linear tetrapyrrole phycocyanobilin in a similar structure to bilirubin. We speculate that there is probably a way of inducing the expression of heme oxygenase 1, with which tissue oxidative stress and inflammation can be inhibited, thus inhibiting pulmonary fibrosis caused by oxidative damage and inflammation of lung. By optimizing the enzymatic hydrolysis process, phycocyanobilin-bound phycocyanin peptide were obtained, and its <i>in vitro</i> antioxidant, anti-inflammatory, and anti-pulmonary fibrosis activities were investigated. The results show that the phycocyanobilin peptide was able to alleviate oxidative and inflammatory damage in cells through the Keap1-Nrf2-HO-1 pathway, which in turn relieved pulmonary fibrosis symptoms.https://www.mdpi.com/1660-3397/20/11/696phycocyaninphycocyanin peptidepulmonary fibrosisinflammatoryoxidative stressheme oxygenases-1 |
| spellingShingle | Run-Ze Liu Wen-Jun Li Juan-Juan Zhang Zheng-Yi Liu Ya Li Chao Liu Song Qin The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em> Marine Drugs phycocyanin phycocyanin peptide pulmonary fibrosis inflammatory oxidative stress heme oxygenases-1 |
| title | The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em> |
| title_full | The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em> |
| title_fullStr | The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em> |
| title_full_unstemmed | The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em> |
| title_short | The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis <em>In Vitro</em> |
| title_sort | inhibitory effect of phycocyanin peptide on pulmonary fibrosis em in vitro em |
| topic | phycocyanin phycocyanin peptide pulmonary fibrosis inflammatory oxidative stress heme oxygenases-1 |
| url | https://www.mdpi.com/1660-3397/20/11/696 |
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