Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a prominent contributor to the pathophysiological processes of traumatic brain injury (TBI). Recently, a potent, selective, small-mole...

Full description

Bibliographic Details
Main Authors: Xin Xu, Dongpei Yin, Honglei Ren, Weiwei Gao, Fei Li, Dongdong Sun, Yingang Wu, Shuai Zhou, Li Lyu, Mengchen Yang, Jianhua Xiong, Lulu Han, Rongcai Jiang, Jianning Zhang
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Neurobiology of Disease
Subjects:
Traumatic brain injury
Neuroinflammation
NLRP3 inflammasome
Interleukin-1β
Microglia
MCC950
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301542

Internet

http://www.sciencedirect.com/science/article/pii/S0969996118301542

Similar Items