Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
Michael B Zemel,1,2 Antje Bruckbauer11NuSirt Sciences Inc, 2Nutrition Department, The University of Tennessee, Knoxville, TN, USABackground: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in r...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-08-01
|
| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Online Access: | http://www.dovepress.com/effects-of-a-leucine-and-pyridoxine-containing-nutraceutical-on-body-w-a14147 |
| _version_ | 1797935959396843520 |
|---|---|
| author | Zemel MB Bruckbauer A |
| author_facet | Zemel MB Bruckbauer A |
| author_sort | Zemel MB |
| collection | DOAJ |
| description | Michael B Zemel,1,2 Antje Bruckbauer11NuSirt Sciences Inc, 2Nutrition Department, The University of Tennessee, Knoxville, TN, USABackground: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape™) containing 2.25 g leucine and 30 mg B6 increased fat oxidation by > 30 g/day in a 28-day randomized controlled trial. The present study evaluated the long-term efficacy of this combination in modulating body weight and composition.Methods: Two 24-week, placebo-controlled, randomized trials, one with weight maintenance (n = 20) and one hypocaloric (-500 kcal/day; n = 24), were conducted using the nutraceutical Nushape in obese subjects.Results: The supplement resulted in fat loss in the maintenance study (-1.12 ± 0.36 and -1.82 ± 0.70 kg at 12 and 24 weeks, P < 0.01 versus placebo) while no change was found in the placebo group. In the hypocaloric study, the supplement group lost up to twice as much weight (6.18 ± 1.02 versus 3.40 ± 0.81 kg at 12 weeks and 8.15 ± 1.33 versus 5.25 ± 1.13 kg at 24 weeks, P < 0.01) and fat (4.96 ± 0.61 versus 2.31 ± 0.53 kg at 12 weeks and 7.00 ± 0.95 versus 4.22 ± 0.74 kg at 24 weeks, P < 0.01) than the placebo group.Conclusion: This nutraceutical combination results in significant fat loss in the absence of caloric restriction and markedly enhances weight and fat loss by 50%–80% over a 24-week period.Keywords: leucine, vitamin B6, pyridoxine, fat loss, weight loss, caloric restriction, adiposity, body composition |
| first_indexed | 2024-04-10T18:23:15Z |
| format | Article |
| id | doaj.art-4801ab0558e749e9bbe0dbd8cf629f51 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:23:15Z |
| publishDate | 2013-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-4801ab0558e749e9bbe0dbd8cf629f512023-02-02T06:52:43ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072013-08-012013default309315Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjectsZemel MBBruckbauer AMichael B Zemel,1,2 Antje Bruckbauer11NuSirt Sciences Inc, 2Nutrition Department, The University of Tennessee, Knoxville, TN, USABackground: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape™) containing 2.25 g leucine and 30 mg B6 increased fat oxidation by > 30 g/day in a 28-day randomized controlled trial. The present study evaluated the long-term efficacy of this combination in modulating body weight and composition.Methods: Two 24-week, placebo-controlled, randomized trials, one with weight maintenance (n = 20) and one hypocaloric (-500 kcal/day; n = 24), were conducted using the nutraceutical Nushape in obese subjects.Results: The supplement resulted in fat loss in the maintenance study (-1.12 ± 0.36 and -1.82 ± 0.70 kg at 12 and 24 weeks, P < 0.01 versus placebo) while no change was found in the placebo group. In the hypocaloric study, the supplement group lost up to twice as much weight (6.18 ± 1.02 versus 3.40 ± 0.81 kg at 12 weeks and 8.15 ± 1.33 versus 5.25 ± 1.13 kg at 24 weeks, P < 0.01) and fat (4.96 ± 0.61 versus 2.31 ± 0.53 kg at 12 weeks and 7.00 ± 0.95 versus 4.22 ± 0.74 kg at 24 weeks, P < 0.01) than the placebo group.Conclusion: This nutraceutical combination results in significant fat loss in the absence of caloric restriction and markedly enhances weight and fat loss by 50%–80% over a 24-week period.Keywords: leucine, vitamin B6, pyridoxine, fat loss, weight loss, caloric restriction, adiposity, body compositionhttp://www.dovepress.com/effects-of-a-leucine-and-pyridoxine-containing-nutraceutical-on-body-w-a14147 |
| spellingShingle | Zemel MB Bruckbauer A Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects Diabetes, Metabolic Syndrome and Obesity |
| title | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
| title_full | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
| title_fullStr | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
| title_full_unstemmed | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
| title_short | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
| title_sort | effects of a leucine and pyridoxine containing nutraceutical on body weight and composition in obese subjects |
| url | http://www.dovepress.com/effects-of-a-leucine-and-pyridoxine-containing-nutraceutical-on-body-w-a14147 |
| work_keys_str_mv | AT zemelmb effectsofaleucineandpyridoxinecontainingnutraceuticalonbodyweightandcompositioninobesesubjects AT bruckbauera effectsofaleucineandpyridoxinecontainingnutraceuticalonbodyweightandcompositioninobesesubjects |