Tissue fibrosis and its correlation with malignancy in canine mammary tumors
Background: Fibrosis is present in several pathologies associated with mammary carcinogenesis. Objective: To evaluate and quantify the fibrosis present in malignant and benign mammary neoplasms in bitches. Methods: Eighty-three samples were divided according to histopathological diagnosis into benig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidad de Antioquia
2018-12-01
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| Series: | Revista Colombiana de Ciencias Pecuarias |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/rccp/article/view/330536 |
| _version_ | 1831519590579961856 |
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| author | Gabriela N. Toledo Marcus A. R. Feliciano Ricardo A. R. Uscategui Geórgia M. Magalhães Gabriela M. Madruga Wilter R. R. Vicente |
| author_facet | Gabriela N. Toledo Marcus A. R. Feliciano Ricardo A. R. Uscategui Geórgia M. Magalhães Gabriela M. Madruga Wilter R. R. Vicente |
| author_sort | Gabriela N. Toledo |
| collection | DOAJ |
| description | Background: Fibrosis is present in several pathologies associated with mammary carcinogenesis. Objective: To evaluate and quantify the fibrosis present in malignant and benign mammary neoplasms in bitches. Methods: Eighty-three samples were divided according to histopathological diagnosis into benign (n= 21) and malignant (n= 62) neoplasms. Haematoxylin-eosin and Masson’s trichrome were used to locate the connective tissue, and the extent of fibrosis was assessed with image software. Results: Benign neoplasms were classified into adenomas (cystic, complex, and tubular), benign mixed tumor, and ductal and lobular hyperplasia. Malignant neoplasms were classified as carcinomas (complex, mixed tumor, in situ tubular, tubulopapillary, and solid). Grade I was the most prevalent histopathological class, followed by grade II and III. Fibrosis was classified as severe, moderate, or discrete. No significant (p>0.05) difference was observed for the percentage of fibrosis between malignant and benign group neoplasms. However, difference (p=0.028) was found for fibrosis percentage between histopathological subtypes of tumors. The benign subtype of lobular hyperplasia presented differences between cystic adenoma and benign mixed tumor. The in situ malignant tubular carcinoma subtype presented differences between solid and tubulopapillary carcinoma. Conclusions: Fibrosis in canine mammary tumors can be estimated with Massons’s trichrome staining. |
| first_indexed | 2024-12-13T17:16:43Z |
| format | Article |
| id | doaj.art-48066fd9d591459d95fce08fd34554ae |
| institution | Directory Open Access Journal |
| issn | 2256-2958 |
| language | English |
| last_indexed | 2024-12-13T17:16:43Z |
| publishDate | 2018-12-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Revista Colombiana de Ciencias Pecuarias |
| spelling | doaj.art-48066fd9d591459d95fce08fd34554ae2022-12-21T23:37:24ZengUniversidad de AntioquiaRevista Colombiana de Ciencias Pecuarias2256-29582018-12-0131429530310.17533/udea.rccp.v31n4a0629669Tissue fibrosis and its correlation with malignancy in canine mammary tumorsGabriela N. Toledo0Marcus A. R. Feliciano1Ricardo A. R. Uscategui2Geórgia M. Magalhães3Gabriela M. Madruga4Wilter R. R. Vicente5São Paulo State UniversitySão Paulo State University, Federal University of Recôncavo da BahiaSão Paulo State UniversityFederal Institute of Education, Science and Technology of the South of Minas GeraisSão Paulo State UniversitySão Paulo State UniversityBackground: Fibrosis is present in several pathologies associated with mammary carcinogenesis. Objective: To evaluate and quantify the fibrosis present in malignant and benign mammary neoplasms in bitches. Methods: Eighty-three samples were divided according to histopathological diagnosis into benign (n= 21) and malignant (n= 62) neoplasms. Haematoxylin-eosin and Masson’s trichrome were used to locate the connective tissue, and the extent of fibrosis was assessed with image software. Results: Benign neoplasms were classified into adenomas (cystic, complex, and tubular), benign mixed tumor, and ductal and lobular hyperplasia. Malignant neoplasms were classified as carcinomas (complex, mixed tumor, in situ tubular, tubulopapillary, and solid). Grade I was the most prevalent histopathological class, followed by grade II and III. Fibrosis was classified as severe, moderate, or discrete. No significant (p>0.05) difference was observed for the percentage of fibrosis between malignant and benign group neoplasms. However, difference (p=0.028) was found for fibrosis percentage between histopathological subtypes of tumors. The benign subtype of lobular hyperplasia presented differences between cystic adenoma and benign mixed tumor. The in situ malignant tubular carcinoma subtype presented differences between solid and tubulopapillary carcinoma. Conclusions: Fibrosis in canine mammary tumors can be estimated with Massons’s trichrome staining.https://revistas.udea.edu.co/index.php/rccp/article/view/330536biological biomarkersbreast cancerdogshistological stainhistopathologymasson’s trichrome |
| spellingShingle | Gabriela N. Toledo Marcus A. R. Feliciano Ricardo A. R. Uscategui Geórgia M. Magalhães Gabriela M. Madruga Wilter R. R. Vicente Tissue fibrosis and its correlation with malignancy in canine mammary tumors Revista Colombiana de Ciencias Pecuarias biological biomarkers breast cancer dogs histological stain histopathology masson’s trichrome |
| title | Tissue fibrosis and its correlation with malignancy in canine mammary tumors |
| title_full | Tissue fibrosis and its correlation with malignancy in canine mammary tumors |
| title_fullStr | Tissue fibrosis and its correlation with malignancy in canine mammary tumors |
| title_full_unstemmed | Tissue fibrosis and its correlation with malignancy in canine mammary tumors |
| title_short | Tissue fibrosis and its correlation with malignancy in canine mammary tumors |
| title_sort | tissue fibrosis and its correlation with malignancy in canine mammary tumors |
| topic | biological biomarkers breast cancer dogs histological stain histopathology masson’s trichrome |
| url | https://revistas.udea.edu.co/index.php/rccp/article/view/330536 |
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