Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia
BackgroundRespiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services.AimThis study aimed to describe the echocardiographic findings of pati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134601/full |
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| author | Samah I. Abohamr Samah I. Abohamr Rami M. Abazid Mohammed K. Alhumaid Abubaker E. Abdulrahim Mubarak A. Aldossari Lamiaa Khedr Rehab H. Werida Haifa S. Alkheledan Yazeed S. Aleid Sara W. Abdelhamid Abdulmohsen Al Mefarrej Ahmed W. Abdelhamid Mohammad Hasan Alaboud Omar T. Alhasan Hanem M. Gomaa Eman Elsheikh Eman Elsheikh |
| author_facet | Samah I. Abohamr Samah I. Abohamr Rami M. Abazid Mohammed K. Alhumaid Abubaker E. Abdulrahim Mubarak A. Aldossari Lamiaa Khedr Rehab H. Werida Haifa S. Alkheledan Yazeed S. Aleid Sara W. Abdelhamid Abdulmohsen Al Mefarrej Ahmed W. Abdelhamid Mohammad Hasan Alaboud Omar T. Alhasan Hanem M. Gomaa Eman Elsheikh Eman Elsheikh |
| author_sort | Samah I. Abohamr |
| collection | DOAJ |
| description | BackgroundRespiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services.AimThis study aimed to describe the echocardiographic findings of patients with COVID-19 infections and their correlations with inflammatory biomarkers, disease severity, and clinical outcomes.MethodsThis observational study was conducted between June 2021 and July 2022. The analysis included all patients diagnosed with COVID-19 who had transthoracic echocardiographic (TTE) scans within 72 h of admission.ResultsThe enrolled patients had a mean age of 55.6 ± 14.7 years, and 66.1% were male. Of the 490 enrolled patients, 203 (41.4%) were admitted to the intensive care unit (ICU). Pre-ICU TTE findings showed significantly higher incidence right ventricular dysfunction (28 [13.8%] vs. 23 [8.0%]; P = 0.04) and left ventricular (LV) regional wall motion abnormalities (55 [27.1%] vs. 29 [10.1%]; p < 0.001) in ICU patients compared to non-ICU patients. In-hospital mortality was 11 (2.2%), all deaths of ICU patients. The most sensitive predictors of ICU admission (p < 0.05): cardiac troponin I level (area under the curve [AUC] = 0.733), followed by hs-CRP (AUC = 0.620), creatine kinase-MB (AUC = 0.617), D-dimer (AUC = 0.599), and lactate dehydrogenase (AUC = 0.567). Binary logistic regression showed that reduced LV ejection fraction (LVEF), elevated pulmonary artery systolic pressure, and dilated right ventricle were echocardiographic predictors of poor outcomes (p < 0.05).ConclusionEchocardiography is a valuable tool in assessing admitted patients with COVID-19. Lower LVEF, pulmonary hypertension, higher D-dimer, C-reactive protein, and B-type natriuretic peptide levels were predictors of poor outcomes. |
| first_indexed | 2024-03-13T09:28:04Z |
| format | Article |
| id | doaj.art-48076a14d19945baa0067aa6fa9acfd7 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T09:28:04Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-48076a14d19945baa0067aa6fa9acfd72023-05-26T04:49:51ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-05-011010.3389/fcvm.2023.11346011134601Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi ArabiaSamah I. Abohamr0Samah I. Abohamr1Rami M. Abazid2Mohammed K. Alhumaid3Abubaker E. Abdulrahim4Mubarak A. Aldossari5Lamiaa Khedr6Rehab H. Werida7Haifa S. Alkheledan8Yazeed S. Aleid9Sara W. Abdelhamid10Abdulmohsen Al Mefarrej11Ahmed W. Abdelhamid12Mohammad Hasan Alaboud13Omar T. Alhasan14Hanem M. Gomaa15Eman Elsheikh16Eman Elsheikh17Department of Cardiology, College of Medicine, Tanta University, Tanta, EgyptHeart Health Center, King Saud medical city, Riyadh, Saudi ArabiaDivision of Cardiology, Department of Medicine, London Health Sciences Centre, Western University London, Ontario, ON, CanadaKing Fahad Medical City, Riyadh, Saudi ArabiaHeart Health Center, King Saud medical city, Riyadh, Saudi ArabiaHeart Health Center, King Saud medical city, Riyadh, Saudi ArabiaDepartment of Cardiology, College of Medicine, Tanta University, Tanta, EgyptClinical Pharmacy & Pharmacy Practice Department, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptInfection Control Administration, King Saud Medical City, Riyadh, Saudi ArabiaHeart Health Center, King Saud medical city, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaHeart Health Center, King Saud medical city, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaHeart Health Center, King Saud medical city, Riyadh, Saudi ArabiaHeart Health Center, King Saud medical city, Riyadh, Saudi ArabiaInfection Control Administration, King Saud Medical City, Riyadh, Saudi ArabiaDepartment of Cardiology, College of Medicine, Tanta University, Tanta, EgyptInternal Medicine Department, King Faisal University, Alahsa, Saudi ArabiaBackgroundRespiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services.AimThis study aimed to describe the echocardiographic findings of patients with COVID-19 infections and their correlations with inflammatory biomarkers, disease severity, and clinical outcomes.MethodsThis observational study was conducted between June 2021 and July 2022. The analysis included all patients diagnosed with COVID-19 who had transthoracic echocardiographic (TTE) scans within 72 h of admission.ResultsThe enrolled patients had a mean age of 55.6 ± 14.7 years, and 66.1% were male. Of the 490 enrolled patients, 203 (41.4%) were admitted to the intensive care unit (ICU). Pre-ICU TTE findings showed significantly higher incidence right ventricular dysfunction (28 [13.8%] vs. 23 [8.0%]; P = 0.04) and left ventricular (LV) regional wall motion abnormalities (55 [27.1%] vs. 29 [10.1%]; p < 0.001) in ICU patients compared to non-ICU patients. In-hospital mortality was 11 (2.2%), all deaths of ICU patients. The most sensitive predictors of ICU admission (p < 0.05): cardiac troponin I level (area under the curve [AUC] = 0.733), followed by hs-CRP (AUC = 0.620), creatine kinase-MB (AUC = 0.617), D-dimer (AUC = 0.599), and lactate dehydrogenase (AUC = 0.567). Binary logistic regression showed that reduced LV ejection fraction (LVEF), elevated pulmonary artery systolic pressure, and dilated right ventricle were echocardiographic predictors of poor outcomes (p < 0.05).ConclusionEchocardiography is a valuable tool in assessing admitted patients with COVID-19. Lower LVEF, pulmonary hypertension, higher D-dimer, C-reactive protein, and B-type natriuretic peptide levels were predictors of poor outcomes.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134601/fullechocardiographyCOVID-19outcomebiomarkerthrombusmortality |
| spellingShingle | Samah I. Abohamr Samah I. Abohamr Rami M. Abazid Mohammed K. Alhumaid Abubaker E. Abdulrahim Mubarak A. Aldossari Lamiaa Khedr Rehab H. Werida Haifa S. Alkheledan Yazeed S. Aleid Sara W. Abdelhamid Abdulmohsen Al Mefarrej Ahmed W. Abdelhamid Mohammad Hasan Alaboud Omar T. Alhasan Hanem M. Gomaa Eman Elsheikh Eman Elsheikh Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia Frontiers in Cardiovascular Medicine echocardiography COVID-19 outcome biomarker thrombus mortality |
| title | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
| title_full | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
| title_fullStr | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
| title_full_unstemmed | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
| title_short | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
| title_sort | association between echocardiographic features and inflammatory biomarkers with clinical outcomes in covid 19 patients in saudi arabia |
| topic | echocardiography COVID-19 outcome biomarker thrombus mortality |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134601/full |
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