Research journey of respirasome
Abstract Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons. Copious r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-01-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13238-019-00681-x |
| _version_ | 1797765256528789504 |
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| author | Meng Wu Jinke Gu Shuai Zong Runyu Guo Tianya Liu Maojun Yang |
| author_facet | Meng Wu Jinke Gu Shuai Zong Runyu Guo Tianya Liu Maojun Yang |
| author_sort | Meng Wu |
| collection | DOAJ |
| description | Abstract Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons. Copious research has been carried out on this lynchpin of respiration. From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1III2IV1, scientists have gradually uncovered the mysterious veil of the electron transport chain (ETC). With the discovery of the mammalian respiratory mega complex I2III2IV2, a new perspective emerges in the research field of the ETC. Behind these advances glitters the light of the revolution in both theory and technology. Here, we give a short review about how scientists ‘see’ the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades. |
| first_indexed | 2024-03-12T20:08:28Z |
| format | Article |
| id | doaj.art-48085945c5284bb8b5be17ab8373463b |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T20:08:28Z |
| publishDate | 2020-01-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-48085945c5284bb8b5be17ab8373463b2023-08-02T01:54:34ZengOxford University PressProtein & Cell1674-800X1674-80182020-01-0111531833810.1007/s13238-019-00681-xResearch journey of respirasomeMeng Wu0Jinke Gu1Shuai Zong2Runyu Guo3Tianya Liu4Maojun Yang5Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityAbstract Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons. Copious research has been carried out on this lynchpin of respiration. From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1III2IV1, scientists have gradually uncovered the mysterious veil of the electron transport chain (ETC). With the discovery of the mammalian respiratory mega complex I2III2IV2, a new perspective emerges in the research field of the ETC. Behind these advances glitters the light of the revolution in both theory and technology. Here, we give a short review about how scientists ‘see’ the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades.https://doi.org/10.1007/s13238-019-00681-xelectron transport chainsupercomplex organizationcellular respirationstructure of respirasomecryo-EMmegacomplex |
| spellingShingle | Meng Wu Jinke Gu Shuai Zong Runyu Guo Tianya Liu Maojun Yang Research journey of respirasome Protein & Cell electron transport chain supercomplex organization cellular respiration structure of respirasome cryo-EM megacomplex |
| title | Research journey of respirasome |
| title_full | Research journey of respirasome |
| title_fullStr | Research journey of respirasome |
| title_full_unstemmed | Research journey of respirasome |
| title_short | Research journey of respirasome |
| title_sort | research journey of respirasome |
| topic | electron transport chain supercomplex organization cellular respiration structure of respirasome cryo-EM megacomplex |
| url | https://doi.org/10.1007/s13238-019-00681-x |
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