Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescence
Abstract Background The knowledge of how the separate Attention-Deficit/Hyperactivity Disorder (ADHD) subdimensions (impulsivity, hyperactivity, and inattention) are associated with nonsuicidal self-injury (NSSI) and suicidal behavior (SB) is limited. The objective of this study was to investigate t...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-04311-5 |
| _version_ | 1827633464679071744 |
|---|---|
| author | Olivia Ojala Ralf Kuja-Halkola Johan Bjureberg Anna Ohlis Martin Cederlöf Eva Norén Selinus Paul Lichtenstein Henrik Larsson Sebastian Lundström Clara Hellner |
| author_facet | Olivia Ojala Ralf Kuja-Halkola Johan Bjureberg Anna Ohlis Martin Cederlöf Eva Norén Selinus Paul Lichtenstein Henrik Larsson Sebastian Lundström Clara Hellner |
| author_sort | Olivia Ojala |
| collection | DOAJ |
| description | Abstract Background The knowledge of how the separate Attention-Deficit/Hyperactivity Disorder (ADHD) subdimensions (impulsivity, hyperactivity, and inattention) are associated with nonsuicidal self-injury (NSSI) and suicidal behavior (SB) is limited. The objective of this study was to investigate the associations of childhood ADHD subdimensions with NSSI and SB in children at risk of neurodevelopmental disorders (NDDs; including ADHD). Methods The sample (N = 391) included twin pairs where at least one twin screened positive for at least one NDD or common comorbidity at age 9 or 12. Data on ADHD subdimensions was collected through a telephone interview with a caregiver/legal guardian at age 9 or 12, and data on NSSI and SB was collected through an in-person clinical assessment at age 15. The associations between the ADHD subdimensions and NSSI or SB were tested in three different models: (1) univariable, (2) together with the other ADHD subdimensions, and (3) in a confounder-adjusted model including other NDD symptoms in addition to ADHD subdimensions, for NSSI and SB separately. Results A total of 32 (8.2%) adolescents reported life-time engagement of NSSI, and 18 (4.6%) SB. Childhood impulsivity was associated with SB and childhood inattention with NSSI, in all models. Hyperactivity was not meaningfully associated with any of the outcomes. Conclusion Impulsivity and inattention, but not hyperactivity, may be of particular importance in understanding SB and NSSI. Brief screening for impulsivity and inattention in childhood could facilitate detection of children vulnerable to NSSI and SB and indicate valuable information for preventive and intervention strategies. |
| first_indexed | 2024-03-09T15:00:32Z |
| format | Article |
| id | doaj.art-4808923007c741138b04909f9c0a2a3d |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-09T15:00:32Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-4808923007c741138b04909f9c0a2a3d2023-11-26T13:56:07ZengBMCBMC Psychiatry1471-244X2022-11-0122111010.1186/s12888-022-04311-5Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescenceOlivia Ojala0Ralf Kuja-Halkola1Johan Bjureberg2Anna Ohlis3Martin Cederlöf4Eva Norén Selinus5Paul Lichtenstein6Henrik Larsson7Sebastian Lundström8Clara Hellner9Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care ServicesDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care ServicesCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care ServicesCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care ServicesRegion Vastmanland – Uppsala University, Centre for Clinical Research, Vastmanland HospitalDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetGillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of GothenburgCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care ServicesAbstract Background The knowledge of how the separate Attention-Deficit/Hyperactivity Disorder (ADHD) subdimensions (impulsivity, hyperactivity, and inattention) are associated with nonsuicidal self-injury (NSSI) and suicidal behavior (SB) is limited. The objective of this study was to investigate the associations of childhood ADHD subdimensions with NSSI and SB in children at risk of neurodevelopmental disorders (NDDs; including ADHD). Methods The sample (N = 391) included twin pairs where at least one twin screened positive for at least one NDD or common comorbidity at age 9 or 12. Data on ADHD subdimensions was collected through a telephone interview with a caregiver/legal guardian at age 9 or 12, and data on NSSI and SB was collected through an in-person clinical assessment at age 15. The associations between the ADHD subdimensions and NSSI or SB were tested in three different models: (1) univariable, (2) together with the other ADHD subdimensions, and (3) in a confounder-adjusted model including other NDD symptoms in addition to ADHD subdimensions, for NSSI and SB separately. Results A total of 32 (8.2%) adolescents reported life-time engagement of NSSI, and 18 (4.6%) SB. Childhood impulsivity was associated with SB and childhood inattention with NSSI, in all models. Hyperactivity was not meaningfully associated with any of the outcomes. Conclusion Impulsivity and inattention, but not hyperactivity, may be of particular importance in understanding SB and NSSI. Brief screening for impulsivity and inattention in childhood could facilitate detection of children vulnerable to NSSI and SB and indicate valuable information for preventive and intervention strategies.https://doi.org/10.1186/s12888-022-04311-5Self-injurySuicidal behaviorNeurodevelopmental disordersADHDAdolescence |
| spellingShingle | Olivia Ojala Ralf Kuja-Halkola Johan Bjureberg Anna Ohlis Martin Cederlöf Eva Norén Selinus Paul Lichtenstein Henrik Larsson Sebastian Lundström Clara Hellner Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescence BMC Psychiatry Self-injury Suicidal behavior Neurodevelopmental disorders ADHD Adolescence |
| title | Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescence |
| title_full | Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescence |
| title_fullStr | Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescence |
| title_full_unstemmed | Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescence |
| title_short | Associations of impulsivity, hyperactivity, and inattention with nonsuicidal self-injury and suicidal behavior: longitudinal cohort study following children at risk for neurodevelopmental disorders into mid-adolescence |
| title_sort | associations of impulsivity hyperactivity and inattention with nonsuicidal self injury and suicidal behavior longitudinal cohort study following children at risk for neurodevelopmental disorders into mid adolescence |
| topic | Self-injury Suicidal behavior Neurodevelopmental disorders ADHD Adolescence |
| url | https://doi.org/10.1186/s12888-022-04311-5 |
| work_keys_str_mv | AT oliviaojala associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT ralfkujahalkola associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT johanbjureberg associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT annaohlis associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT martincederlof associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT evanorenselinus associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT paullichtenstein associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT henriklarsson associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT sebastianlundstrom associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence AT clarahellner associationsofimpulsivityhyperactivityandinattentionwithnonsuicidalselfinjuryandsuicidalbehaviorlongitudinalcohortstudyfollowingchildrenatriskforneurodevelopmentaldisordersintomidadolescence |