Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study
Background: Low dose reactive cow's milk (CM) allergic children are at high risk of persistent CM allergy and a positive oral food challenge (OFC). The present study aimed to evaluate if the results of a very low dose (VL) OFC with these children contributes to better management of CM allergy....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-07-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015001008 |
| _version_ | 1811310788787306496 |
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| author | Yu Okada Noriyuki Yanagida Sakura Sato Motohiro Ebisawa |
| author_facet | Yu Okada Noriyuki Yanagida Sakura Sato Motohiro Ebisawa |
| author_sort | Yu Okada |
| collection | DOAJ |
| description | Background: Low dose reactive cow's milk (CM) allergic children are at high risk of persistent CM allergy and a positive oral food challenge (OFC). The present study aimed to evaluate if the results of a very low dose (VL) OFC with these children contributes to better management of CM allergy.
Methods: We retrospectively reviewed subjects with CM allergy who underwent a VL OFC with 3 mL heated CM and had a previous allergic reaction to <25 mL heated CM in the 2 years before the OFC. Subjects who passed the OFC were defined as VL tolerant, and subjects who failed were defined as VL reactive. VL tolerant subjects increased the dose to 25 mL heated CM either during an OFC in our hospital or gradually at home.
Results: Of the 83 subjects (median age, 4.3 years; range, 1.0–12.9 years) who were included, 41 (49.4%) were VL tolerant, and 42 (51.6%) were VL reactive. Thirty-nine VL reactive subjects had skin and/or respiratory symptoms during the OFC. Most reactions could be treated with an antihistamine and/or a nebulized β2 agonist. The VL tolerant subjects consumed 3 mL heated CM or 10 g butter. Within the year following the OFC, 18 VL tolerant subjects (45.0%), but none of the VL reactive subjects, were able to consume 25 mL heated CM (p < 0.001).
Conclusions: A VL OFC allows the management of some low dose reactive CM allergic children to change from complete avoidance to partial intake of CM. |
| first_indexed | 2024-04-13T10:05:23Z |
| format | Article |
| id | doaj.art-480b257aaf4d4f999d6e032558499306 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-13T10:05:23Z |
| publishDate | 2015-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-480b257aaf4d4f999d6e0325584993062022-12-22T02:51:06ZengElsevierAllergology International1323-89302015-07-0164327227610.1016/j.alit.2015.04.002Better management of cow's milk allergy using a very low dose food challenge test: A retrospective studyYu Okada0Noriyuki Yanagida1Sakura Sato2Motohiro Ebisawa3Department of Pediatrics, Sagamihara National Hospital, Kanagawa, JapanDepartment of Pediatrics, Sagamihara National Hospital, Kanagawa, JapanDepartment of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanDepartment of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanBackground: Low dose reactive cow's milk (CM) allergic children are at high risk of persistent CM allergy and a positive oral food challenge (OFC). The present study aimed to evaluate if the results of a very low dose (VL) OFC with these children contributes to better management of CM allergy. Methods: We retrospectively reviewed subjects with CM allergy who underwent a VL OFC with 3 mL heated CM and had a previous allergic reaction to <25 mL heated CM in the 2 years before the OFC. Subjects who passed the OFC were defined as VL tolerant, and subjects who failed were defined as VL reactive. VL tolerant subjects increased the dose to 25 mL heated CM either during an OFC in our hospital or gradually at home. Results: Of the 83 subjects (median age, 4.3 years; range, 1.0–12.9 years) who were included, 41 (49.4%) were VL tolerant, and 42 (51.6%) were VL reactive. Thirty-nine VL reactive subjects had skin and/or respiratory symptoms during the OFC. Most reactions could be treated with an antihistamine and/or a nebulized β2 agonist. The VL tolerant subjects consumed 3 mL heated CM or 10 g butter. Within the year following the OFC, 18 VL tolerant subjects (45.0%), but none of the VL reactive subjects, were able to consume 25 mL heated CM (p < 0.001). Conclusions: A VL OFC allows the management of some low dose reactive CM allergic children to change from complete avoidance to partial intake of CM.http://www.sciencedirect.com/science/article/pii/S1323893015001008Milk hypersensitivityDisease managementFood allergyFood hypersensitivitySpecific IgE |
| spellingShingle | Yu Okada Noriyuki Yanagida Sakura Sato Motohiro Ebisawa Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study Allergology International Milk hypersensitivity Disease management Food allergy Food hypersensitivity Specific IgE |
| title | Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study |
| title_full | Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study |
| title_fullStr | Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study |
| title_full_unstemmed | Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study |
| title_short | Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study |
| title_sort | better management of cow s milk allergy using a very low dose food challenge test a retrospective study |
| topic | Milk hypersensitivity Disease management Food allergy Food hypersensitivity Specific IgE |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015001008 |
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