The disruption of proteostasis in neurodegenerative disorders
Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2015-06-01
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| Series: | AIMS Molecular Science |
| Subjects: | |
| Online Access: | http://www.aimspress.com/Molecular/article/311/fulltext.html |
| _version_ | 1811344237090832384 |
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| author | Ana Jalles Patrícia Maciel |
| author_facet | Ana Jalles Patrícia Maciel |
| author_sort | Ana Jalles |
| collection | DOAJ |
| description | Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases. |
| first_indexed | 2024-04-13T19:44:13Z |
| format | Article |
| id | doaj.art-480c10a0ba544ba4b0188e6f09d57d21 |
| institution | Directory Open Access Journal |
| issn | 2372-0301 |
| language | English |
| last_indexed | 2024-04-13T19:44:13Z |
| publishDate | 2015-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-480c10a0ba544ba4b0188e6f09d57d212022-12-22T02:32:47ZengAIMS PressAIMS Molecular Science2372-03012015-06-012325929310.3934/molsci.2015.3.259201503259The disruption of proteostasis in neurodegenerative disordersAna JallesPatrícia MacielCells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.http://www.aimspress.com/Molecular/article/311/fulltext.htmlproteostasismolecular chaperonesunfolded protein responseproteasomeautophagytherapeutic strategies |
| spellingShingle | Ana Jalles Patrícia Maciel The disruption of proteostasis in neurodegenerative disorders AIMS Molecular Science proteostasis molecular chaperones unfolded protein response proteasome autophagy therapeutic strategies |
| title | The disruption of proteostasis in neurodegenerative disorders |
| title_full | The disruption of proteostasis in neurodegenerative disorders |
| title_fullStr | The disruption of proteostasis in neurodegenerative disorders |
| title_full_unstemmed | The disruption of proteostasis in neurodegenerative disorders |
| title_short | The disruption of proteostasis in neurodegenerative disorders |
| title_sort | disruption of proteostasis in neurodegenerative disorders |
| topic | proteostasis molecular chaperones unfolded protein response proteasome autophagy therapeutic strategies |
| url | http://www.aimspress.com/Molecular/article/311/fulltext.html |
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