Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia.

Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia.

There is no current approved therapy for the ultimately lethal neuro- and cardio-degenerative disease Friedreich's ataxia (FA). Finding minimally-invasive molecular biomarkers of disease progression and drug effect could support smaller, shorter clinical trials. Since we and others have noted a...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Genki Hayashi, Gino Cortopassi
Formatua:	Artikulua
Hizkuntza:	English
Argitaratua:	Public Library of Science (PLoS) 2016-01-01
Saila:	PLoS ONE
Sarrera elektronikoa:	http://europepmc.org/articles/PMC4831832?pdf=render

Antzeko izenburuak

Sexual dimorphism in a mouse model of Friedreich’s ataxia with severe cardiomyopathy
nork: Lili Salinas, et al.
Argitaratua: (2024-10-01)

Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion.
nork: Marissa Z McMackin, et al.
Argitaratua: (2019-01-01)

Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia.
nork: Mittal Jasoliya, et al.
Argitaratua: (2019-01-01)

Genetics and Friedreich Ataxia
nork: J Gordon Millichap
Argitaratua: (2002-06-01)

Genetics of Friedreich Ataxia
nork: J Gordon Millichap
Argitaratua: (1997-06-01)

Friedreich’s Ataxia: A Neuronal Point of View on the Oxidative Stress Hypothesis
nork: Barbara Carletti, et al.
Argitaratua: (2014-09-01)

Molecular Defects in Friedreich’s Ataxia: Convergence of Oxidative Stress and Cytoskeletal Abnormalities
nork: Frances M. Smith, et al.
Argitaratua: (2020-11-01)

Late-Onset Friedreich’s Ataxia
nork: J Gordon Millichap
Argitaratua: (1993-08-01)

Friedreich’s Ataxia with Retained Reflexes
nork: J Gordon Millichap
Argitaratua: (1995-04-01)

Friedreich's Ataxia and Glucose Metabolism
nork: J Gordon Millichap
Argitaratua: (1988-08-01)

5-Hydroxytryptophan in Friedreich’s Ataxia
nork: J Gordon Millichap
Argitaratua: (1995-06-01)

Iron Storage in Friedreich’s Ataxia
nork: J Gordon Millichap
Argitaratua: (1999-08-01)

Tissue Iron in Friedreich Ataxia
nork: Arnulf H Koeppen
Argitaratua: (2024-01-01)

Respiratory Function in Friedreich’s Ataxia
nork: Elena Vinante, et al.
Argitaratua: (2022-08-01)

The pathogenesis of cardiomyopathy in Friedreich ataxia.
nork: Arnulf H Koeppen, et al.
Argitaratua: (2015-01-01)

Is Friedreich ataxia an epigenetic disorder?
nork: Kumari Daman, et al.
Argitaratua: (2012-01-01)

Epigenetic modification of the frataxin gene for the treatment of Friedreich’s ataxia
nork: Vilema Enriquez, MG
Argitaratua: (2018)

Friedreich ataxia in a family from Mali, West Africa/Friedreich ataxia in a Malian family
nork: Cheick A. K. Cissé, et al.
Argitaratua: (2021-05-01)

Advantages and Limitations of Gene Therapy and Gene Editing for Friedreich’s Ataxia
nork: Anusha Sivakumar, et al.
Argitaratua: (2022-05-01)

Antioxidant Therapies and Oxidative Stress in Friedreich’s Ataxia: The Right Path or Just a Diversion?
nork: Laura R. Rodríguez, et al.
Argitaratua: (2020-07-01)

Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia.
nork: Vincent Paupe, et al.
Argitaratua: (2009-01-01)

Exploring neuropsychiatric symptoms in Friedreich ataxia
nork: Simona Karamazovova, et al.
Argitaratua: (2024-11-01)

Friedreichs ataxia in a diabetic patient
nork: Inna Igorevna Klefortova, et al.
Argitaratua: (2010-06-01)

Friedreich's Ataxia – A Clinical Diagnosis
nork: Md. Fekarul Islam, et al.
Argitaratua: (2015-01-01)

Clinical and Genetic Diagnosis of Friedreich’s Ataxia
nork: J Gordon Millichap
Argitaratua: (1998-05-01)

Emerging antioxidant therapies in Friedreich’s ataxia
nork: Fred Jonathan Edzeamey, et al.
Argitaratua: (2024-02-01)

An Overview of the Ferroptosis Hallmarks in Friedreich’s Ataxia
nork: Riccardo Turchi, et al.
Argitaratua: (2020-10-01)

Perspectives on current models of Friedreich’s ataxia
nork: Simge Kelekçi, et al.
Argitaratua: (2022-08-01)

Anaesthesia for a patient with Friedreich′s ataxia
nork: Ilango Ganesan
Argitaratua: (2011-01-01)

Otoneurological Abnormalities in Patients with Friedreich's Ataxia
nork: Bianca Simone Zeigelboim, et al.
Argitaratua: (2017-01-01)

Epigenetic-based therapies for Friedreich ataxia
nork: Chiranjeevi eSandi, et al.
Argitaratua: (2014-06-01)

Predictors of loss of ambulation in Friedreich's ataxia
nork: Christian Rummey, et al.
Argitaratua: (2020-01-01)

Hepatic mitochondrial dysfunction in Friedreich Ataxia
nork: Stüwe Sven H, et al.
Argitaratua: (2011-11-01)

Prediction of the disease course in Friedreich ataxia
nork: Christian Hohenfeld, et al.
Argitaratua: (2022-11-01)

Friedreich’s Ataxia-A Case Report
nork: Tahreem Muntaha, et al.
Argitaratua: (2018-11-01)

Friedreich ataxia- pathogenesis and implications for therapies
nork: Martin B. Delatycki, et al.
Argitaratua: (2019-12-01)

At-home wearable-based monitoring predicts clinical measures and biological biomarkers of disease severity in Friedreich’s Ataxia
nork: Ram Kinker Mishra, et al.
Argitaratua: (2024-10-01)

Perspectives of the Friedreich ataxia community on gene therapy clinical trials
nork: Shandra J. Trantham, et al.
Argitaratua: (2024-03-01)

Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
nork: Timothy E Richardson, et al.
Argitaratua: (2012-01-01)

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models
nork: Rosella Abeti, et al.
Argitaratua: (2018-07-01)