Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia.

Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia.

There is no current approved therapy for the ultimately lethal neuro- and cardio-degenerative disease Friedreich's ataxia (FA). Finding minimally-invasive molecular biomarkers of disease progression and drug effect could support smaller, shorter clinical trials. Since we and others have noted a...

Bibliografski detalji
Glavni autori:	Genki Hayashi, Gino Cortopassi
Format:	Članak
Jezik:	English
Izdano:	Public Library of Science (PLoS) 2016-01-01
Serija:	PLoS ONE
Online pristup:	http://europepmc.org/articles/PMC4831832?pdf=render

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Clinical and Genetic Diagnosis of Friedreich’s Ataxia
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