Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1

Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1

ABSTRACT The gp41 membrane-proximal external region (MPER) is a target for broadly neutralizing antibody responses against human immunodeficiency virus type 1 (HIV-1). However, replication-defective virus vaccines currently under evaluation in clinical trials do not efficiently elicit MPER-specific...

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Bibliographic Details
Main Authors: Karl W. Boehme, Mine' Ikizler, Jason A. Iskarpatyoti, J. Denise Wetzel, Jordan Willis, James E. Crowe, Celia C. LaBranche, David C. Montefiori, Gregory J. Wilson, Terence S. Dermody
Format: Article
Language:English
Published: American Society for Microbiology 2016-06-01
Series:mSphere
Subjects:
human immunodeficiency virus
immunization
live vector vaccines
neutralizing antibodies
reovirus
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00086-16

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