Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is associated with dysbiosis and intestinal barrier dysfunction, as indicated by epithelial hyperpermeability and high levels of mucosal-associated bacteria. Changes in gut microbiota may be correlated with IBD pathogenesis. Additionally, microbe-based treatments cou...
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11422 |
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| author | Chun-Chao Chang Chih-Yi Liu I-Chia Su Yuarn-Jang Lee Hsing-Jung Yeh Wen-Chao Chen Chih-Jui Yu Wei-Yu Kao Yu-Chuan Liu Chi-Jung Huang |
| author_facet | Chun-Chao Chang Chih-Yi Liu I-Chia Su Yuarn-Jang Lee Hsing-Jung Yeh Wen-Chao Chen Chih-Jui Yu Wei-Yu Kao Yu-Chuan Liu Chi-Jung Huang |
| author_sort | Chun-Chao Chang |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is associated with dysbiosis and intestinal barrier dysfunction, as indicated by epithelial hyperpermeability and high levels of mucosal-associated bacteria. Changes in gut microbiota may be correlated with IBD pathogenesis. Additionally, microbe-based treatments could mitigate clinical IBD symptoms. Plasmon-activated water (PAW) is known to have an anti-inflammatory potential. In this work, we studied the association between the anti-inflammatory ability of PAW and intestinal microbes, thereby improving IBD treatment. We examined the PAW-induced changes in the colonic immune activity and microbiota of mice by immunohistochemistry and next generation sequencing, determined whether drinking PAW can mitigate IBD induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) and dysbiosis through mice animal models. The effects of specific probiotic species on mice with TNBS-induced IBD were also investigated. Experimental results indicated that PAW could change the local inflammation in the intestinal microenvironment. Moreover, the abundance of <i>Akkermansia</i> spp. was degraded in the TNBS-treated mice but elevated in the PAW-drinking mice. Daily rectal injection of <i>Akkermansia muciniphila</i>, a potential probiotic species in <i>Akkermansia</i> spp., also improved the health of the mice. Correspondingly, both PAW consumption and increasing the intestinal abundance of <i>Akkermansia muciniphila</i> can mitigate IBD in mice. These findings indicate that increasing the abundance of <i>Akkermansia muciniphila</i> in the gut through PAW consumption or other methods may mitigate IBD in mice with clinically significant IBD. |
| first_indexed | 2024-03-09T21:40:01Z |
| format | Article |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:40:01Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-480f073879fe42819e929c173c7519bf2023-11-23T20:32:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123191142210.3390/ijms231911422Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel DiseaseChun-Chao Chang0Chih-Yi Liu1I-Chia Su2Yuarn-Jang Lee3Hsing-Jung Yeh4Wen-Chao Chen5Chih-Jui Yu6Wei-Yu Kao7Yu-Chuan Liu8Chi-Jung Huang9Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, TaiwanDepartment of Pathology, Sijhih Cathay General Hospital, New Taipei 221, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, TaiwanDepartment of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Medical Research, Cathay General Hospital, Taipei 106, TaiwanInflammatory bowel disease (IBD) is associated with dysbiosis and intestinal barrier dysfunction, as indicated by epithelial hyperpermeability and high levels of mucosal-associated bacteria. Changes in gut microbiota may be correlated with IBD pathogenesis. Additionally, microbe-based treatments could mitigate clinical IBD symptoms. Plasmon-activated water (PAW) is known to have an anti-inflammatory potential. In this work, we studied the association between the anti-inflammatory ability of PAW and intestinal microbes, thereby improving IBD treatment. We examined the PAW-induced changes in the colonic immune activity and microbiota of mice by immunohistochemistry and next generation sequencing, determined whether drinking PAW can mitigate IBD induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) and dysbiosis through mice animal models. The effects of specific probiotic species on mice with TNBS-induced IBD were also investigated. Experimental results indicated that PAW could change the local inflammation in the intestinal microenvironment. Moreover, the abundance of <i>Akkermansia</i> spp. was degraded in the TNBS-treated mice but elevated in the PAW-drinking mice. Daily rectal injection of <i>Akkermansia muciniphila</i>, a potential probiotic species in <i>Akkermansia</i> spp., also improved the health of the mice. Correspondingly, both PAW consumption and increasing the intestinal abundance of <i>Akkermansia muciniphila</i> can mitigate IBD in mice. These findings indicate that increasing the abundance of <i>Akkermansia muciniphila</i> in the gut through PAW consumption or other methods may mitigate IBD in mice with clinically significant IBD.https://www.mdpi.com/1422-0067/23/19/11422plasmon-activated waterinflammatory bowel disease<i>Akkermansia muciniphila</i>gut microbiotamicrobial biomarker |
| spellingShingle | Chun-Chao Chang Chih-Yi Liu I-Chia Su Yuarn-Jang Lee Hsing-Jung Yeh Wen-Chao Chen Chih-Jui Yu Wei-Yu Kao Yu-Chuan Liu Chi-Jung Huang Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease International Journal of Molecular Sciences plasmon-activated water inflammatory bowel disease <i>Akkermansia muciniphila</i> gut microbiota microbial biomarker |
| title | Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease |
| title_full | Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease |
| title_fullStr | Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease |
| title_full_unstemmed | Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease |
| title_short | Functional Plasmon-Activated Water Increases <i>Akkermansia muciniphila</i> Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease |
| title_sort | functional plasmon activated water increases i akkermansia muciniphila i abundance in gut microbiota to ameliorate inflammatory bowel disease |
| topic | plasmon-activated water inflammatory bowel disease <i>Akkermansia muciniphila</i> gut microbiota microbial biomarker |
| url | https://www.mdpi.com/1422-0067/23/19/11422 |
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