Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid
Currently, a promising direction of study is the use of biologically active coordination compounds in the pharmacopoeia and the creation of effective bactericidal drugs, biomaterials, and enzyme modulators on that basis. The paper considers a coordination germanium compound with 2-amino-3-hydroxybut...
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MDPI AG
2024-03-01
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author | Alena V. Kadomtseva Georgy M. Mochalov Maria A. Zasovskaya Anatoly M. Ob’edkov |
author_facet | Alena V. Kadomtseva Georgy M. Mochalov Maria A. Zasovskaya Anatoly M. Ob’edkov |
author_sort | Alena V. Kadomtseva |
collection | DOAJ |
description | Currently, a promising direction of study is the use of biologically active coordination compounds in the pharmacopoeia and the creation of effective bactericidal drugs, biomaterials, and enzyme modulators on that basis. The paper considers a coordination germanium compound with 2-amino-3-hydroxybutanoic acid. The prospects for the use of the compound in medicine are outlined. This work is aimed at solving the problems regarding the synthesis of biologically active compounds with a wide spectrum of actions. The structure and composition of the coordination compound have been established through calculation and experimental methods. The biocidal (bactericidal and fungicidal) activity of germanium-containing compounds against a number of bacteria and microscopic fungi has been studied. Using the quantum-chemical method with density functional theory (DFT, B3LYP/6–311++G(2d,2p)), the theoretical IR spectrum of the compound was calculated. The structure of the coordination compound and the structure of the intermediates at all stages of the synthesis process were established by calculation. |
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language | English |
last_indexed | 2024-04-24T18:10:09Z |
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spelling | doaj.art-480f9c42d37043aeaee5b585322c1d502024-03-27T13:47:07ZengMDPI AGInorganics2304-67402024-03-011238310.3390/inorganics12030083Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic AcidAlena V. Kadomtseva0Georgy M. Mochalov1Maria A. Zasovskaya2Anatoly M. Ob’edkov3Department of General Chemistry, Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Minin and Pozharsky Square, 10/1, 603005 Nizhny Novgorod, RussiaDepartment of Nanotechnology and Biotechnology, Alekseev Nizhny Novgorod State Technical University, St. Minina, 24, 603950 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, Ukhta State Technical University, St. Pervomaiskaya 13, 169300 Ukhta, RussiaG.A. Razuvaev Institute of Organometallic Chemistry of the Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaCurrently, a promising direction of study is the use of biologically active coordination compounds in the pharmacopoeia and the creation of effective bactericidal drugs, biomaterials, and enzyme modulators on that basis. The paper considers a coordination germanium compound with 2-amino-3-hydroxybutanoic acid. The prospects for the use of the compound in medicine are outlined. This work is aimed at solving the problems regarding the synthesis of biologically active compounds with a wide spectrum of actions. The structure and composition of the coordination compound have been established through calculation and experimental methods. The biocidal (bactericidal and fungicidal) activity of germanium-containing compounds against a number of bacteria and microscopic fungi has been studied. Using the quantum-chemical method with density functional theory (DFT, B3LYP/6–311++G(2d,2p)), the theoretical IR spectrum of the compound was calculated. The structure of the coordination compound and the structure of the intermediates at all stages of the synthesis process were established by calculation.https://www.mdpi.com/2304-6740/12/3/83germanium compoundssynthesisphysicochemical analysisbiological activityquantum chemical modelingdensity functional theory |
spellingShingle | Alena V. Kadomtseva Georgy M. Mochalov Maria A. Zasovskaya Anatoly M. Ob’edkov Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid Inorganics germanium compounds synthesis physicochemical analysis biological activity quantum chemical modeling density functional theory |
title | Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid |
title_full | Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid |
title_fullStr | Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid |
title_full_unstemmed | Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid |
title_short | Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid |
title_sort | synthesis structure and biological activity of the germanium dioxide complex compound with 2 amino 3 hydroxybutanoic acid |
topic | germanium compounds synthesis physicochemical analysis biological activity quantum chemical modeling density functional theory |
url | https://www.mdpi.com/2304-6740/12/3/83 |
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