Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) Herb
To understand the impacts of different processing methods on the composition and effects of the herb<em> Saussurea laniceps</em> (SL), the present study report the first comparison of the chemical constituents of aqueous and ethanolic SL extracts using chromatographic ana...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/17/6/7183 |
| _version_ | 1818109067611078656 |
|---|---|
| author | Zhijun Yang Zhongzhen Zhao Hubiao Chen Zhiling Yu Hongwing Lo Tao Yi |
| author_facet | Zhijun Yang Zhongzhen Zhao Hubiao Chen Zhiling Yu Hongwing Lo Tao Yi |
| author_sort | Zhijun Yang |
| collection | DOAJ |
| description | To understand the impacts of different processing methods on the composition and effects of the herb<em> Saussurea laniceps</em> (SL), the present study report the first comparison of the chemical constituents of aqueous and ethanolic SL extracts using chromatographic analysis, and to compare their pharmacological effects in a mouse anti-inflammatory, anti-nociceptive model and an <em>in vitro</em> anti-oxidant test. Chemical comparison demonstrated that the types of chemicals in the two extracts were identical, but the contents of the main constituents in the aqueous extract were lower than those of the ethanolic extract. A transesterification of dicaffeoylquinic acids took place in the aqueous extract during boiling. As for pharmacological effects, oral administration of aqueous and ethanolic SL extracts significantly inhibited croton oil-induced mice ear edema, and significantly inhibited acetic acid-induced mice writhings, respectively. In the DPPH anti-oxidant activity test, the IC<sub>50</sub> values were calculated as 409.6 mg/L and 523.4 mg/L for the ethanolic and aqueous extracts, respectively. The inhibitory effects of the ethanolic extract were more potent than those of the aqueous extract in all pharmacological tests, although there was no significant difference. This study suggests that the two preparations should be distinguished when used. |
| first_indexed | 2024-12-11T02:25:22Z |
| format | Article |
| id | doaj.art-48109816a3fc4e20be4badfb0e728896 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T02:25:22Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-48109816a3fc4e20be4badfb0e7288962022-12-22T01:23:56ZengMDPI AGMolecules1420-30492012-06-011767183719410.3390/molecules17067183Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) HerbZhijun YangZhongzhen ZhaoHubiao ChenZhiling YuHongwing LoTao YiTo understand the impacts of different processing methods on the composition and effects of the herb<em> Saussurea laniceps</em> (SL), the present study report the first comparison of the chemical constituents of aqueous and ethanolic SL extracts using chromatographic analysis, and to compare their pharmacological effects in a mouse anti-inflammatory, anti-nociceptive model and an <em>in vitro</em> anti-oxidant test. Chemical comparison demonstrated that the types of chemicals in the two extracts were identical, but the contents of the main constituents in the aqueous extract were lower than those of the ethanolic extract. A transesterification of dicaffeoylquinic acids took place in the aqueous extract during boiling. As for pharmacological effects, oral administration of aqueous and ethanolic SL extracts significantly inhibited croton oil-induced mice ear edema, and significantly inhibited acetic acid-induced mice writhings, respectively. In the DPPH anti-oxidant activity test, the IC<sub>50</sub> values were calculated as 409.6 mg/L and 523.4 mg/L for the ethanolic and aqueous extracts, respectively. The inhibitory effects of the ethanolic extract were more potent than those of the aqueous extract in all pharmacological tests, although there was no significant difference. This study suggests that the two preparations should be distinguished when used.http://www.mdpi.com/1420-3049/17/6/7183<em>Saussurea laniceps</em>transesterificationanti-inflammatoryanti-nociceptiveanti-oxidant |
| spellingShingle | Zhijun Yang Zhongzhen Zhao Hubiao Chen Zhiling Yu Hongwing Lo Tao Yi Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) Herb Molecules <em>Saussurea laniceps</em> transesterification anti-inflammatory anti-nociceptive anti-oxidant |
| title | Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) Herb |
| title_full | Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) Herb |
| title_fullStr | Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) Herb |
| title_full_unstemmed | Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) Herb |
| title_short | Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (<em>Saussurea laniceps</em>) Herb |
| title_sort | comparison of the chemical composition and pharmacological effects of the aqueous and ethanolic extracts from a tibetan snow lotus lt em gt saussurea laniceps lt em gt herb |
| topic | <em>Saussurea laniceps</em> transesterification anti-inflammatory anti-nociceptive anti-oxidant |
| url | http://www.mdpi.com/1420-3049/17/6/7183 |
| work_keys_str_mv | AT zhijunyang comparisonofthechemicalcompositionandpharmacologicaleffectsoftheaqueousandethanolicextractsfromatibetansnowlotusltemgtsaussurealanicepsltemgtherb AT zhongzhenzhao comparisonofthechemicalcompositionandpharmacologicaleffectsoftheaqueousandethanolicextractsfromatibetansnowlotusltemgtsaussurealanicepsltemgtherb AT hubiaochen comparisonofthechemicalcompositionandpharmacologicaleffectsoftheaqueousandethanolicextractsfromatibetansnowlotusltemgtsaussurealanicepsltemgtherb AT zhilingyu comparisonofthechemicalcompositionandpharmacologicaleffectsoftheaqueousandethanolicextractsfromatibetansnowlotusltemgtsaussurealanicepsltemgtherb AT hongwinglo comparisonofthechemicalcompositionandpharmacologicaleffectsoftheaqueousandethanolicextractsfromatibetansnowlotusltemgtsaussurealanicepsltemgtherb AT taoyi comparisonofthechemicalcompositionandpharmacologicaleffectsoftheaqueousandethanolicextractsfromatibetansnowlotusltemgtsaussurealanicepsltemgtherb |