Severe COVID-19: NLRP3 Inflammasome Dysregulated

Severe COVID-19: NLRP3 Inflammasome Dysregulated

SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous adjuvant activity necessary to mount a proper adaptive immune response against the virus. Heterogeneous response of COVID-19 patients could be attributed to differences in not being able to properly downregulate NLRP3 i...

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Bibliographic Details
Main Authors: Daan F. van den Berg, Anje A. te Velde
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
COVID-19
NLRP3 inflammasome
therapy
endogenous adjuvant activity
HMGB1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01580/full

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