Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa
Abstract Introduction A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (< 50 years), with no unique histopathological or molecular characteristics. Anatomical site as well as microsatellite instability (MSI) status have shown to be associate...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-10185-3 |
| _version_ | 1811335363177742336 |
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| author | Michelle McCabe Clement Penny Pumza Magangane Sheefa Mirza Yvonne Perner |
| author_facet | Michelle McCabe Clement Penny Pumza Magangane Sheefa Mirza Yvonne Perner |
| author_sort | Michelle McCabe |
| collection | DOAJ |
| description | Abstract Introduction A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (< 50 years), with no unique histopathological or molecular characteristics. Anatomical site as well as microsatellite instability (MSI) status have shown to be associated with different clinicopathological and molecular features. This study aimed to ascertain key histopathological features in microsatellite stable (MSS) and low-frequency MSI (MSI-L) patients, to provide insight into the mechanism of the disease. Methods A retrospective cohort (2011–2015) of MSS/MSI-L CRC patient samples diagnosed at Charlotte Maxeke Johannesburg Academic Hospital was analyzed. Samples were categorized by site [right colon cancer (RCC) versus left (LCC)], ethnicity [IA versus other ethnic groups (OEG)] and MSI status (MSI-L vs MSS). T-test, Fischer’s exact and Chi-square tests were conducted. Results IA patients with LCC demonstrated an increased prevalence in males, sigmoid colon, signet-ring-cell morphology, MSI-L with BAT25/26 marker instability and advanced disease association. Conclusion This study revealed distinct histopathological features for LCC, and suggests BAT25 and BAT26 as negative prognostic markers in African CRC patients. Larger confirmatory studies are recommended. |
| first_indexed | 2024-04-13T17:23:01Z |
| format | Article |
| id | doaj.art-48116f5f2a9d4251a385571a1b390d48 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T17:23:01Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-48116f5f2a9d4251a385571a1b390d482022-12-22T02:37:54ZengBMCBMC Cancer1471-24072022-10-0122111010.1186/s12885-022-10185-3Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South AfricaMichelle McCabe0Clement Penny1Pumza Magangane2Sheefa Mirza3Yvonne Perner4Division of Anatomical Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory ServicesDepartment of Internal Medicine, Faculty of Health Sciences, University of the WitwatersrandDivision of Anatomical Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory ServicesDepartment of Internal Medicine, Faculty of Health Sciences, University of the WitwatersrandDivision of Anatomical Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory ServicesAbstract Introduction A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (< 50 years), with no unique histopathological or molecular characteristics. Anatomical site as well as microsatellite instability (MSI) status have shown to be associated with different clinicopathological and molecular features. This study aimed to ascertain key histopathological features in microsatellite stable (MSS) and low-frequency MSI (MSI-L) patients, to provide insight into the mechanism of the disease. Methods A retrospective cohort (2011–2015) of MSS/MSI-L CRC patient samples diagnosed at Charlotte Maxeke Johannesburg Academic Hospital was analyzed. Samples were categorized by site [right colon cancer (RCC) versus left (LCC)], ethnicity [IA versus other ethnic groups (OEG)] and MSI status (MSI-L vs MSS). T-test, Fischer’s exact and Chi-square tests were conducted. Results IA patients with LCC demonstrated an increased prevalence in males, sigmoid colon, signet-ring-cell morphology, MSI-L with BAT25/26 marker instability and advanced disease association. Conclusion This study revealed distinct histopathological features for LCC, and suggests BAT25 and BAT26 as negative prognostic markers in African CRC patients. Larger confirmatory studies are recommended.https://doi.org/10.1186/s12885-022-10185-3Colorectal cancerAfricanMicrosatellite stableLow level microsatellite instabilityBAT25BAT26 |
| spellingShingle | Michelle McCabe Clement Penny Pumza Magangane Sheefa Mirza Yvonne Perner Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa BMC Cancer Colorectal cancer African Microsatellite stable Low level microsatellite instability BAT25 BAT26 |
| title | Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa |
| title_full | Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa |
| title_fullStr | Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa |
| title_full_unstemmed | Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa |
| title_short | Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa |
| title_sort | left sided colorectal cancer distinct in indigenous african patients compared to other ethnic groups in south africa |
| topic | Colorectal cancer African Microsatellite stable Low level microsatellite instability BAT25 BAT26 |
| url | https://doi.org/10.1186/s12885-022-10185-3 |
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