Multidrug-Resistant Tuberculosis in Europe, 2010–2011
Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2015-03-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/21/3/14-1343_article |
| _version_ | 1818175206522355712 |
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| author | Gunar Günther Frank van Leth Sofia Alexandru Neus Altet Korkut Avsar Didi Bang Raisa Barbuta Graham Bothamley Ana Ciobanu Valeriu Crudu Manfred Davilovits Martin Dedicoat Raquel Duarte Gina Gualano Heinke Kunst Wiel de Lange Vaira Leimane Cecile Magis-Escurra Anne-Marie McLaughlin Inge Muylle Veronika Polcová Emanuele Pontali Christina Popa Rudolf Rumetshofer Alena Skrahina Varvara Solodovnikova Victor Spinu Simon Tiberi Piret Viiklepp Christoph Lange |
| author_facet | Gunar Günther Frank van Leth Sofia Alexandru Neus Altet Korkut Avsar Didi Bang Raisa Barbuta Graham Bothamley Ana Ciobanu Valeriu Crudu Manfred Davilovits Martin Dedicoat Raquel Duarte Gina Gualano Heinke Kunst Wiel de Lange Vaira Leimane Cecile Magis-Escurra Anne-Marie McLaughlin Inge Muylle Veronika Polcová Emanuele Pontali Christina Popa Rudolf Rumetshofer Alena Skrahina Varvara Solodovnikova Victor Spinu Simon Tiberi Piret Viiklepp Christoph Lange |
| author_sort | Gunar Günther |
| collection | DOAJ |
| description | Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non–MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010–2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to ≥1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fluoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe. |
| first_indexed | 2024-12-11T19:56:37Z |
| format | Article |
| id | doaj.art-481172337f5f4b46a0bf7abbbc22a263 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T19:56:37Z |
| publishDate | 2015-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-481172337f5f4b46a0bf7abbbc22a2632022-12-22T00:52:38ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-03-0121340941610.3201/eid2103.141343Multidrug-Resistant Tuberculosis in Europe, 2010–2011Gunar GüntherFrank van LethSofia AlexandruNeus AltetKorkut AvsarDidi BangRaisa BarbutaGraham BothamleyAna CiobanuValeriu CruduManfred DavilovitsMartin DedicoatRaquel DuarteGina GualanoHeinke KunstWiel de LangeVaira LeimaneCecile Magis-EscurraAnne-Marie McLaughlinInge MuylleVeronika PolcováEmanuele PontaliChristina PopaRudolf RumetshoferAlena SkrahinaVarvara SolodovnikovaVictor SpinuSimon TiberiPiret ViikleppChristoph LangeDrug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non–MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010–2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to ≥1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fluoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.https://wwwnc.cdc.gov/eid/article/21/3/14-1343_articletuberculosis and other mycobacteriamultidrug-resistant tuberculosisMDR TBextensively drug-resistant tuberculosisXDR TBdrug resistance |
| spellingShingle | Gunar Günther Frank van Leth Sofia Alexandru Neus Altet Korkut Avsar Didi Bang Raisa Barbuta Graham Bothamley Ana Ciobanu Valeriu Crudu Manfred Davilovits Martin Dedicoat Raquel Duarte Gina Gualano Heinke Kunst Wiel de Lange Vaira Leimane Cecile Magis-Escurra Anne-Marie McLaughlin Inge Muylle Veronika Polcová Emanuele Pontali Christina Popa Rudolf Rumetshofer Alena Skrahina Varvara Solodovnikova Victor Spinu Simon Tiberi Piret Viiklepp Christoph Lange Multidrug-Resistant Tuberculosis in Europe, 2010–2011 Emerging Infectious Diseases tuberculosis and other mycobacteria multidrug-resistant tuberculosis MDR TB extensively drug-resistant tuberculosis XDR TB drug resistance |
| title | Multidrug-Resistant Tuberculosis in Europe, 2010–2011 |
| title_full | Multidrug-Resistant Tuberculosis in Europe, 2010–2011 |
| title_fullStr | Multidrug-Resistant Tuberculosis in Europe, 2010–2011 |
| title_full_unstemmed | Multidrug-Resistant Tuberculosis in Europe, 2010–2011 |
| title_short | Multidrug-Resistant Tuberculosis in Europe, 2010–2011 |
| title_sort | multidrug resistant tuberculosis in europe 2010 2011 |
| topic | tuberculosis and other mycobacteria multidrug-resistant tuberculosis MDR TB extensively drug-resistant tuberculosis XDR TB drug resistance |
| url | https://wwwnc.cdc.gov/eid/article/21/3/14-1343_article |
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