The cytosolic hyperoxidation-sensitive and -robust Leishmania peroxiredoxins cPRX1 and cPRX2 are both dispensable for parasite infectivity
Typical two-cysteine peroxiredoxins (2-Cys-PRXs) are H2O2-metabolizing enzymes whose activity relies on two cysteine residues. Protists of the family Trypanosomatidae invariably express one cytosolic 2-Cys-PRX (cPRX1). However, the Leishmaniinae sub-family features an additional isoform (cPRX2), alm...
Main Authors: | Helena Castro, Maria Inês Rocha, Margarida Duarte, Jordi Vilurbina, Ana Georgina Gomes-Alves, Teresa Leao, Filipa Dias, Bruce Morgan, Marcel Deponte, Ana Maria Tomás |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2024-05-01
|
Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231724000983 |
Similar Items
-
Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling
by: Yosup Kim, et al.
Published: (2019-06-01) -
Hyperoxidation of Peroxiredoxins and Effects on Physiology of <i>Drosophila</i>
by: Austin McGinnis, et al.
Published: (2021-04-01) -
Hyperoxidized Peroxiredoxin 2 Is a Possible Biomarker for the Diagnosis of Obstructive Sleep Apnea
by: Shin Koike, et al.
Published: (2022-12-01) -
Effects of Serine or Threonine in the Active Site of Typical 2-Cys Prx on Hyperoxidation Susceptibility and on Chaperone Activity
by: Carlos A. Tairum, et al.
Published: (2021-06-01) -
Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert-butyl hydroperoxide in human red blood cells
by: Y.I. Ishida, et al.
Published: (2014-01-01)