Recent progress in mapping the emerging landscape of the small-cell lung cancer genome
Small cell lung cancer: Genome insights for improving treatment Alterations in the small cell lung cancer (SCLC) genome are critical for disease progression and relapse. A complete map of the genome in cancerous cells would greatly improve the chances of successfully treating this deadly disease. SC...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-12-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0349-5 |
| _version_ | 1818594682259636224 |
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| author | Kee-Beom Kim Colin T. Dunn Kwon-Sik Park |
| author_facet | Kee-Beom Kim Colin T. Dunn Kwon-Sik Park |
| author_sort | Kee-Beom Kim |
| collection | DOAJ |
| description | Small cell lung cancer: Genome insights for improving treatment Alterations in the small cell lung cancer (SCLC) genome are critical for disease progression and relapse. A complete map of the genome in cancerous cells would greatly improve the chances of successfully treating this deadly disease. SCLC is often detected too late, and only five per cent of patients survive beyond five years after diagnosis. While the disease initially responds to standard chemotherapy, the cancer cells quickly build resistance and relapse follows. Kwon-Sik Park at the University of Virginia, Charlottesville, US, and co-workers reviewed current understanding of SCLC genome alterations. The latest research highlights substantial variations in the SCLC genome between patients, with implications for existing treatment regimens. Researchers have made considerable progress in profiling the genome, with significant alterations, mutations and potential therapeutic targets now being explored in genetically engineered mouse models and patient-derived tumor models. |
| first_indexed | 2024-12-16T11:04:00Z |
| format | Article |
| id | doaj.art-481293375a814f82a5796626219ba5a0 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-16T11:04:00Z |
| publishDate | 2019-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-481293375a814f82a5796626219ba5a02022-12-21T22:33:55ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-12-01511211310.1038/s12276-019-0349-5Recent progress in mapping the emerging landscape of the small-cell lung cancer genomeKee-Beom Kim0Colin T. Dunn1Kwon-Sik Park2Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia School of MedicineSchool of Medicine MD Program, Case Western Reserve UniversityDepartments of Microbiology, Immunology, and Cancer Biology, University of Virginia School of MedicineSmall cell lung cancer: Genome insights for improving treatment Alterations in the small cell lung cancer (SCLC) genome are critical for disease progression and relapse. A complete map of the genome in cancerous cells would greatly improve the chances of successfully treating this deadly disease. SCLC is often detected too late, and only five per cent of patients survive beyond five years after diagnosis. While the disease initially responds to standard chemotherapy, the cancer cells quickly build resistance and relapse follows. Kwon-Sik Park at the University of Virginia, Charlottesville, US, and co-workers reviewed current understanding of SCLC genome alterations. The latest research highlights substantial variations in the SCLC genome between patients, with implications for existing treatment regimens. Researchers have made considerable progress in profiling the genome, with significant alterations, mutations and potential therapeutic targets now being explored in genetically engineered mouse models and patient-derived tumor models.https://doi.org/10.1038/s12276-019-0349-5 |
| spellingShingle | Kee-Beom Kim Colin T. Dunn Kwon-Sik Park Recent progress in mapping the emerging landscape of the small-cell lung cancer genome Experimental and Molecular Medicine |
| title | Recent progress in mapping the emerging landscape of the small-cell lung cancer genome |
| title_full | Recent progress in mapping the emerging landscape of the small-cell lung cancer genome |
| title_fullStr | Recent progress in mapping the emerging landscape of the small-cell lung cancer genome |
| title_full_unstemmed | Recent progress in mapping the emerging landscape of the small-cell lung cancer genome |
| title_short | Recent progress in mapping the emerging landscape of the small-cell lung cancer genome |
| title_sort | recent progress in mapping the emerging landscape of the small cell lung cancer genome |
| url | https://doi.org/10.1038/s12276-019-0349-5 |
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