Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus

Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus

ABSTRACTPreventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (H...

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Bibliographic Details
Main Authors: Tae Un Yang, Juan C. Vargas-Zambrano, Hang A Park, Chae Won Jung, Dongwook Kim, Youngmee Jee
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Hepatitis B vaccine
mother-to-child transmission
hepatitis B virus
schedule
interval
immunoprophylaxis
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2023.2278940
Description
Summary:ABSTRACTPreventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (HBsAg)-positive mothers from a Korean national database 38,411 (97.7%) had completed timely immunophylaxis with HepB-BD 41,572 (99.8%) with hepatitis B immune globulin, and 1027 (2.6%) were HBsAg-positive at ≥ 9 months. Maternal factors (i.e. HepB e-antigen status, age, or nationality) were associated with an increased risk of infection whereas short gestational length decreased it. The HepB-BD – HepB-SD interval (<8 vs. ≥8 weeks) did not alter the risk.
ISSN:2164-5515
2164-554X

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