Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus
ABSTRACTPreventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (H...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2023.2278940 |
| _version_ | 1827381094972915712 |
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| author | Tae Un Yang Juan C. Vargas-Zambrano Hang A Park Chae Won Jung Dongwook Kim Youngmee Jee |
| author_facet | Tae Un Yang Juan C. Vargas-Zambrano Hang A Park Chae Won Jung Dongwook Kim Youngmee Jee |
| author_sort | Tae Un Yang |
| collection | DOAJ |
| description | ABSTRACTPreventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (HBsAg)-positive mothers from a Korean national database 38,411 (97.7%) had completed timely immunophylaxis with HepB-BD 41,572 (99.8%) with hepatitis B immune globulin, and 1027 (2.6%) were HBsAg-positive at ≥ 9 months. Maternal factors (i.e. HepB e-antigen status, age, or nationality) were associated with an increased risk of infection whereas short gestational length decreased it. The HepB-BD – HepB-SD interval (<8 vs. ≥8 weeks) did not alter the risk. |
| first_indexed | 2024-03-08T13:49:11Z |
| format | Article |
| id | doaj.art-48161c8a25554ddf8f04fc479a9a8e20 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-08T13:49:11Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-48161c8a25554ddf8f04fc479a9a8e202024-01-16T06:44:22ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-12-0119310.1080/21645515.2023.2278940Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virusTae Un Yang0Juan C. Vargas-Zambrano1Hang A Park2Chae Won Jung3Dongwook Kim4Youngmee Jee5Faculty of Medicine, University of Helsinki, Helsinki, FinlandGlobal Medical, Sanofi, Lyon, FranceDepartment of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of KoreaNational Institute of Organ, Tissue and Blood Management, Ministry of Health and Welfare, Seoul, Republic of KoreaDivision of Immunization, Bureau of Healthcare Safety and Immunization, Korea Disease Control and Prevention Agency, Cheongju, Republic of KoreaKorea Disease Control and Prevention Agency, Cheongju, Republic of KoreaABSTRACTPreventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (HBsAg)-positive mothers from a Korean national database 38,411 (97.7%) had completed timely immunophylaxis with HepB-BD 41,572 (99.8%) with hepatitis B immune globulin, and 1027 (2.6%) were HBsAg-positive at ≥ 9 months. Maternal factors (i.e. HepB e-antigen status, age, or nationality) were associated with an increased risk of infection whereas short gestational length decreased it. The HepB-BD – HepB-SD interval (<8 vs. ≥8 weeks) did not alter the risk.https://www.tandfonline.com/doi/10.1080/21645515.2023.2278940Hepatitis B vaccinemother-to-child transmissionhepatitis B virusscheduleintervalimmunoprophylaxis |
| spellingShingle | Tae Un Yang Juan C. Vargas-Zambrano Hang A Park Chae Won Jung Dongwook Kim Youngmee Jee Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus Human Vaccines & Immunotherapeutics Hepatitis B vaccine mother-to-child transmission hepatitis B virus schedule interval immunoprophylaxis |
| title | Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus |
| title_full | Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus |
| title_fullStr | Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus |
| title_full_unstemmed | Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus |
| title_short | Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus |
| title_sort | effect of the interval between birth and second dose of hepatitis b vaccine on perinatal transmission of hepatitis b virus |
| topic | Hepatitis B vaccine mother-to-child transmission hepatitis B virus schedule interval immunoprophylaxis |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2023.2278940 |
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